| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MPR1; MPRI; CD222; CIMPR; M6P-R |
| WB Predicted band size | 274 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human IGF2R |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IGF2R抗体的3篇示例参考文献(注：内容为示例性概括，实际文献需通过学术数据库查询)：
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1. **文献名称**: "IGF2R expression in human cancers: A comparative immunohistochemical study"
**作者**: Oates AJ, et al.
**摘要**: 研究利用特异性IGF2R抗体分析多种癌症组织中的受体表达水平，发现IGF2R在乳腺癌和结直肠癌中表达显著下调，提示其作为潜在肿瘤标志物的可能性。
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2. **文献名称**: "Targeting IGF2R with monoclonal antibodies for cancer therapy"
**作者**: Mathieu C, et al.
**摘要**: 开发了一种新型抗IGF2R单克隆抗体，体外实验表明其可通过阻断配体结合抑制肿瘤细胞增殖，并在小鼠模型中显著减少肿瘤生长。
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3. **文献名称**: "Epitope mapping of IGF2R using polyclonal antibodies"
**作者**: Tolleson SJ, et al.
**摘要**: 通过多克隆抗体定位IGF2R的抗原表位区域，确定其关键结合域位于受体的胞外结构域，为抗体药物设计提供结构基础。
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4. **文献名称**: "IGF2R antibody validation in clinical diagnostics"
**作者**: Lee H, et al.
**摘要**: 验证了商业IGF2R抗体在免疫组化(IHC)中的特异性与敏感性，强调标准化检测流程对临床病理诊断的重要性。
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建议通过PubMed、Web of Science或Google Scholar以“IGF2R antibody”为关键词检索最新文献。
The insulin-like growth factor 2 receptor (IGF2R), also known as the cation-independent mannose-6-phosphate receptor, is a transmembrane protein involved in lysosome-targeting pathways and receptor-mediated endocytosis. It binds insulin-like growth factor 2 (IGF2), a key mitogen regulating fetal growth, and targets it for degradation, thereby modulating cell proliferation and differentiation. IGF2R also interacts with other ligands, including TGF-β and granzyme B, and plays roles in tumor suppression, immune regulation, and tissue homeostasis. Dysregulation of IGF2R is linked to cancers, developmental disorders, and neurodegenerative diseases.
IGF2R antibodies are tools used to study receptor expression, localization, and function in research. They enable detection of IGF2R via techniques like Western blotting, immunohistochemistry, and flow cytometry. In cancer research, these antibodies help assess IGF2R’s role as a tumor suppressor, as its loss or mutation is associated with hepatocellular carcinoma, breast cancer, and other malignancies. Additionally, IGF2R-targeting antibodies are explored therapeutically to block oncogenic signaling or deliver cytotoxic agents in precision oncology. Commercial IGF2R antibodies vary in specificity, targeting epitopes in extracellular or cytoplasmic domains. Validation remains critical due to potential cross-reactivity with related receptors. Overall, IGF2R antibodies are pivotal in elucidating the receptor’s biological significance and clinical potential.
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