| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | HAK6; KV1.7 |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human KCNA7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KCNA7抗体的模拟参考文献示例(文献为假设性示例，建议通过学术数据库验证真实文献)：
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1. **文献名称**：*Characterization of KCNA7 Antibody Specificity in Cardiac Tissue*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种针对KCNA7钾通道蛋白的高特异性多克隆抗体，验证了其在人类和小鼠心脏组织中的免疫反应性。Western blot和免疫组化结果显示，该抗体能有效识别KCNA7蛋白，并揭示了其在心肌细胞膜上的定位，为心律失常相关研究提供了工具。
2. **文献名称**：*KCNA7 Expression in Neurodegenerative Disorders: An Immunohistochemical Study*
**作者**：Lee B, et al.
**摘要**：通过使用KCNA7抗体，研究者分析了阿尔茨海默病和帕金森病患者脑组织中KCNA7的表达变化。结果显示，KCNA7蛋白在病变区域的神经元中表达显著下调，提示其可能与神经兴奋性失衡相关。
3. **文献名称**：*Development of a Monoclonal Antibody for KCNA7 with Applications in Cancer Research*
**作者**：Garcia C, et al.
**摘要**：文章报道了一种新型抗KCNA7单克隆抗体的制备及验证过程。该抗体在结肠癌和乳腺癌细胞系中显示出高灵敏度和特异性，并发现KCNA7表达与肿瘤细胞增殖迁移能力呈负相关。
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**备注**：以上文献为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索(关键词如“KCNA7 antibody”、“KCNA7 potassium channel”)。真实研究可能侧重KCNA7在电生理、疾病模型或抗体技术开发中的应用。
The KCNA7 antibody targets the potassium voltage-gated channel subfamily A member 7 (KCNA7), a protein encoded by the *KCNA7* gene. This channel belongs to the Shaker-related potassium channel family, which regulates action potential repolarization in excitable cells. KCNA7 forms tetrameric channels that facilitate potassium ion efflux, contributing to cellular electrical stability, particularly in cardiac and neuronal tissues. Structurally, it contains six transmembrane segments (S1-S6), with the S4 region acting as a voltage sensor.
KCNA7 is expressed in the heart, skeletal muscle, and brain, where it influences excitability and signaling. Dysregulation or mutations in KCNA7 are linked to arrhythmias, neurological disorders, and some cancers. Antibodies against KCNA7 are critical tools for studying its expression, localization, and functional roles. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate channel distribution in tissues or disease models.
Research on KCNA7 antibodies has advanced understanding of potassium channelopathies and potential therapeutic targets. For example, altered KCNA7 expression is observed in atrial fibrillation, suggesting its role in cardiac electrical abnormalities. These antibodies also aid in exploring interactions with auxiliary subunits or drugs modulating channel activity. Commercial KCNA7 antibodies are typically validated for specificity using knockout controls or peptide-blocking assays. Ongoing studies focus on clarifying its physiological impact and translational relevance in channel-related diseases.
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