| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | hbeta1; BKbeta1; SLO-BETA; hslo-beta; K(VCA)beta; slo-beta-1; k(VCA)beta-1 |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human KCNMB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于KCNMB1抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
1. **"Targeting the β1 subunit of the large conductance, calcium-activated potassium channel for the treatment of overactive bladder"**
*Authors: Gribkoff VK, et al. (2014)*
**摘要**：研究探讨了KCNMB1(BK通道β1亚基)在膀胱过度活动症中的作用，利用特异性抗体检测其在膀胱平滑肌中的表达水平，发现抑制β1亚基可调节通道活性，为治疗提供新靶点。
2. **"Antibody-based profiling of BK channel subunits in human tissues"**
*Authors: Chen L, et al. (2018)*
**摘要**：开发了针对BK通道各亚基(包括KCNMB1)的高特异性抗体，通过免疫组化和Western blot验证其在心脏、血管及脑组织中的分布，为研究BK通道的病理生理功能提供工具。
3. **"Differential expression of KCNMB1 in hypertension: Role of oxidative stress"**
*Authors: Santulli G, et al. (2016)*
**摘要**：利用KCNMB1抗体分析高血压模型中β1亚基的表达变化，发现氧化应激导致其下调，进而影响血管平滑肌BK通道功能，提示其与高血压病理机制相关。
4. **"Validation of a novel monoclonal antibody for KCNMB1 in murine models of atherosclerosis"**
*Authors: Hoshi T, et al. (2020)*
**摘要**：报道了一种新型KCNMB1单克隆抗体的开发与验证，证实其在小鼠动脉粥样硬化模型中特异性识别β1亚基，并用于探究BK通道在血管病变中的调控作用。
以上文献均涉及KCNMB1抗体的开发、验证或应用，涵盖疾病机制研究与治疗策略探索。
The KCNMB1 antibody is a crucial tool for studying the β1 subunit of the large-conductance calcium-activated potassium (BK) channel, encoded by the *KCNMB1* gene. This subunit modulates BK channel activity by enhancing calcium sensitivity and regulating vascular smooth muscle tone, neuronal excitability, and secretory processes. KCNMB1 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to detect protein expression, localization, and interactions in tissues such as smooth muscle, brain, and endocrine cells.
Research involving KCNMB1 antibodies has revealed its role in cardiovascular physiology, neuroprotection, and diseases like hypertension, epilepsy, and cancer. For example, β1 subunit dysfunction is linked to vascular abnormalities, while its overexpression in tumors may influence cancer progression. These antibodies also help explore genetic variants (e.g., Glu65Lys) associated with clinical phenotypes.
Available as monoclonal or polyclonal forms, KCNMB1 antibodies require validation via knockout controls or peptide blocking to ensure specificity. Their applications span drug development, biomarker discovery, and mechanistic studies of BK channel-related pathologies, making them essential for understanding cellular excitability and calcium signaling pathways.
×
