| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ARMS |
| WB Predicted band size | 197 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Synthetic peptide of human KIDINS220 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KIDINS220抗体的3篇参考文献示例(基于模拟生成，非真实文献)：
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1. **文献名称**: *KIDINS220/ARMS interacts with the NuRD complex to regulate synaptic plasticity and cognition*
**作者**: Cortés, A., et al.
**摘要**: 本研究利用KIDINS220特异性抗体，通过免疫共沉淀和质谱分析，发现KIDINS220与NuRD染色质重塑复合物相互作用。实验表明，该互作调控海马神经元突触可塑性和小鼠的学习记忆功能，提示KIDINS220在表观遗传调控中的新角色。
2. **文献名称**: *KIDINS220 deficiency disrupts neurotrophin signalling and leads to neurodevelopmental disorders*
**作者**: Ledesma-Terrón, M., et al.
**摘要**: 通过Western blot和免疫荧光技术，作者发现KIDINS220抗体在小鼠脑组织中的表达模式与神经营养因子(如BDNF)信号通路密切相关。基因敲除模型显示，KIDINS220缺失导致神经元迁移异常和轴突导向缺陷，提示其在神经发育疾病中的潜在致病机制。
3. **文献名称**: *KIDINS220 as a biomarker in melanoma progression: Insights from antibody-based profiling*
**作者**: Schmieg, H., et al.
**摘要**: 该研究利用KIDINS220单克隆抗体对黑色素瘤组织样本进行免疫组化分析，发现KIDINS220的高表达与肿瘤侵袭性和转移相关。机制研究表明，KIDINS220通过调控MAPK信号通路促进癌细胞迁移，为靶向治疗提供了新思路。
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**注**：以上文献为模拟生成，实际研究中建议通过PubMed或Google Scholar以“KIDINS220 antibody”为关键词检索真实文献。若需具体文章，可提供更详细的研究方向(如疾病模型、实验技术等)。
**Background of KIDINS220 Antibody**
KIDINS220 (Kinase D-Interacting Substrate of 220 kDa), also known as ARMS (Ankyrin Repeat-Rich Membrane Spanning protein), is a transmembrane scaffolding protein implicated in neuronal development, survival, and signaling. It interacts with neurotrophin receptors (e.g., TrkA, TrkB) and downstream effectors like Ras/MAPK and PLCγ pathways, regulating axonal growth, synaptic plasticity, and vesicle trafficking.
KIDINS220 antibodies are essential tools for studying its expression, localization, and functional roles. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect KIDINS220 in tissues or cultured cells. Research highlights its involvement in neurological disorders (e.g., Alzheimer’s disease, Huntington’s disease) and cancers (e.g., neuroblastoma, glioblastoma), where dysregulated KIDINS220 expression correlates with disease progression.
Antibodies targeting specific epitopes (e.g., N-terminal or C-terminal regions) help dissect its post-translational modifications and interactions. Recent studies also explore KIDINS220’s role in cardiovascular and immune systems, broadening its therapeutic relevance. Validated KIDINS220 antibodies are critical for advancing insights into its dual roles as a signaling hub and potential biomarker.
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