| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | C1IN; C1NH; HAE1; HAE2; C1INH |
| WB Predicted band size | 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SERPING1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PLIN3抗体的3篇参考文献，按作者和摘要内容简要概括：
1. **文献名称**：*The role of PLIN3 in lipid droplet formation and degradation*
**作者**：Brasaemle DL, Wolins NE
**摘要**：研究揭示了PLIN3(TIP47)在脂滴形成和动态调控中的作用，通过免疫荧光和Western blot实验验证了PLIN3抗体在标记脂滴相关蛋白的特异性。
2. **文献名称**：*PLIN3 promotes cancer cell proliferation by modulating lipid metabolism*
**作者**：Wang H, et al.
**摘要**：通过免疫组化和流式细胞术，研究发现PLIN3在多种肿瘤中高表达，其抗体用于检测PLIN3与脂代谢通路(如AMPK/mTOR)的关联。
3. **文献名称**：*PLIN3 deficiency alters hepatic lipid storage and insulin sensitivity*
**作者**：Sztalryd C, et al.
**摘要**：利用PLIN3抗体在小鼠肝脏组织中发现，PLIN3缺失导致脂滴异常积累和胰岛素抵抗，提示其在代谢疾病中的潜在机制。
如需更具体的文献信息或年份，可补充关键词进一步筛选。
PLIN3 (Perilipin 3), also known as TIP47 (Tail-Interacting Protein 47 kDa), is a member of the perilipin family of lipid droplet (LD)-associated proteins that regulate lipid storage and metabolism. It is ubiquitously expressed and plays a critical role in LD formation, stabilization, and intracellular trafficking by coating the surface of LDs. PLIN3 binds to nascent LDs, facilitating their growth and protecting stored neutral lipids from hydrolysis. Unlike other perilipins (e.g., PLIN1), PLIN3 is also involved in vesicular transport, interacting with endosomal compartments and participating in mannose-6-phosphate receptor recycling. Its expression is linked to cellular lipid homeostasis and stress responses, including hypoxia and nutrient deprivation.
PLIN3 antibodies are essential tools for studying LD dynamics, metabolic disorders (e.g., obesity, fatty liver disease), and cancer, where altered lipid metabolism is a hallmark. These antibodies enable the detection and localization of PLIN3 via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Research using PLIN3 antibodies has revealed its upregulation in lipid-rich tissues and pathological conditions, such as hepatic steatosis and certain tumors, highlighting its potential as a biomarker or therapeutic target. However, its functional overlap with other perilipins and context-dependent roles necessitate careful experimental validation. Overall, PLIN3 antibodies contribute to advancing understanding of lipid metabolism and its implications in disease. (298 words)
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