| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human PGLYRP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3条关于PGLYRP1抗体的参考文献示例(内容基于学术研究主题的常见方向，非真实文献)：
1. **文献名称**：*PGLYRP1 Antibody Reveals Elevated Expression in Psoriatic Skin Lesions*
**作者**：Chen L, et al.
**摘要**：研究通过免疫组化技术，利用PGLYRP1特异性抗体检测银屑病患者皮肤组织中的表达，发现其显著高于健康对照组，提示其参与皮肤免疫异常调控。
2. **文献名称**：*Anti-PGLYRP1 Monoclonal Antibody Attenuates Sepsis-Induced Inflammation in Murine Models*
**作者**：Wang X, et al.
**摘要**：开发了一种靶向PGLYRP1的单克隆抗体，实验表明其能抑制脓毒症模型小鼠中过度炎症反应，降低促炎因子水平，为潜在治疗策略提供依据。
3. **文献名称**：*PGLYRP1 as a Biomarker in Rheumatoid Arthritis: Detection via ELISA*
**作者**：Kim J, et al.
**摘要**：通过ELISA试剂盒(基于PGLYRP1抗体)分析类风湿性关节炎患者血清，发现PGLYRP1水平与疾病活动度正相关，提示其作为炎症标志物的潜力。
4. **文献名称**：*PGLYRP1 Antibody Localization in Gut Epithelium and Its Role in Microbiome Interaction*
**作者**：Garcia R, et al.
**摘要**：利用免疫荧光和Western blot技术，研究PGLYRP1抗体在肠道上皮细胞的定位，揭示其通过调控共生菌群维持肠道屏障功能的机制。
---
注：以上文献为示例，实际引用时需查询真实数据库(如PubMed)并核实原文信息。
Peptidoglycan Recognition Protein 1 (PGLYRP1), also known as TAG-7. is a secreted pattern recognition receptor (PRR) that plays a critical role in innate immunity. It belongs to the PGRP family, which specifically binds to peptidoglycan (PGN), a key component of bacterial cell walls. PGLYRP1 is expressed in immune cells (e.g., neutrophils, macrophages) and epithelial tissues, where it contributes to microbial sensing and host defense. Its antibacterial mechanism involves direct bactericidal activity through PGN hydrolysis or synergistic action with other antimicrobial peptides, as well as modulation of inflammatory responses via interactions with Toll-like receptors (TLRs) or nucleotide-binding oligomerization domain (NOD) pathways.
PGLYRP1 antibodies are essential tools for studying its function in infection, inflammation, and cancer. They enable detection of PGLYRP1 expression in tissues or bodily fluids (e.g., serum, saliva) and are used in techniques like ELISA, Western blotting, immunohistochemistry, and flow cytometry. Commercially available antibodies (polyclonal or monoclonal) are typically raised in rabbits or mice against specific epitopes, often validated using knockout models or blocking assays. Research highlights PGLYRP1's dual role: it protects against bacterial sepsis but may exacerbate chronic inflammation (e.g., rheumatoid arthritis) or tumor progression in certain contexts. Dysregulation of PGLYRP1 has been linked to inflammatory bowel disease, psoriasis, and cancer metastasis, making its antibodies valuable for diagnostic and therapeutic exploration.
×
