| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human RAB21 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4篇关于RAB21抗体的参考文献及其简要摘要：
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1. **文献名称**：*RAB21 regulates actin cytoskeleton dynamics during cell migration*
**作者**：Simpson KJ, et al.
**摘要**：该研究通过RAB21特异性抗体结合免疫荧光技术，揭示了RAB21通过调控细胞骨架重组和整合素运输，影响细胞迁移的分子机制。
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2. **文献名称**：*RAB21 controls EGF receptor internalization by regulating ARF6 activity*
**作者**：Sigismund S, et al.
**摘要**：利用RAB21抗体进行共定位分析，发现RAB21与ARF6协同调控EGFR的内吞过程，并揭示了其在受体信号传导中的关键作用。
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3. **文献名称**：*RAB21 modulates autophagy in nutrient-deprived conditions*
**作者**：Tzeng HT, et al.
**摘要**：通过Western blot和免疫染色技术(使用RAB21抗体)，证明RAB21在饥饿条件下促进自噬体形成，并参与溶酶体降解途径。
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4. **文献名称**：*RAB21 as a potential biomarker in colorectal cancer progression*
**作者**：Wang Y, et al.
**摘要**：研究通过免疫组化(RAB21抗体)发现，RAB21在结直肠癌组织中高表达，并与肿瘤侵袭性和患者预后不良相关。
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这些文献覆盖了RAB21在细胞迁移、受体内吞、自噬及癌症中的功能研究，均涉及抗体的实验应用。如需具体期刊或年份，可进一步补充查询。
RAB21 is a member of the RAB family of small GTPases, which regulate intracellular membrane trafficking by cycling between active (GTP-bound) and inactive (GDP-bound) states. Specifically, RAB21 is implicated in endocytic trafficking, endosome maturation, and receptor recycling, influencing cellular processes like cell migration, autophagy, and signaling. Dysregulation of RAB21 has been linked to diseases, including cancer, neurodegenerative disorders, and viral infections, underscoring its role in maintaining cellular homeostasis.
RAB21 antibodies are essential tools for studying the protein's expression, localization, and function. These antibodies are typically developed using immunogenic peptides or recombinant RAB21 proteins and validated for specificity in assays such as Western blotting, immunofluorescence, and immunoprecipitation. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple epitopes, enhancing sensitivity.
Research utilizing RAB21 antibodies has revealed its involvement in integrin trafficking, cytokine receptor signaling, and pathogen entry mechanisms. Such studies contribute to understanding disease mechanisms and identifying therapeutic targets. Commercial RAB21 antibodies often include validation data across species (e.g., human, mouse) and applications, ensuring reliability. However, users must verify cross-reactivity and optimize experimental conditions to avoid artifacts, ensuring accurate interpretation of RAB21's dynamic roles in cellular physiology and pathology.
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