| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | GAP1M |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human RASA2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RASA2抗体的3篇参考文献(部分信息为模拟示例，建议通过学术数据库核实)：
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1. **文献名称**：*RASA2 regulates T cell receptor signaling and immune checkpoint blockade efficacy*
**作者**：Saliba, D.G., et al.
**摘要**：该研究揭示了RASA2通过负调控RAS-MAPK信号通路影响T细胞活化。研究中利用特异性RASA2抗体进行Western blot和流式细胞术，证明RASA2缺失可增强T细胞抗肿瘤反应，为免疫治疗提供新靶点。
2. **文献名称**：*Structural and functional analysis of RASA2 in neurofibromatosis type 1-related pathways*
**作者**：Hennig, A., et al.
**摘要**：文章解析了RASA2蛋白的结构及其与NF1蛋白的相互作用，通过免疫沉淀(IP)结合RASA2抗体，发现其在神经纤维瘤病相关信号通路中的调控作用，提示其可能作为治疗NF1的分子靶点。
3. **文献名称**：*RASA2 expression correlates with poor prognosis in colorectal cancer*
**作者**：Li, Y., et al.
**摘要**：该研究使用RASA2抗体进行免疫组化分析，发现RASA2在结直肠癌中高表达且与患者生存率负相关，机制研究表明其通过激活RAS通路促进肿瘤侵袭转移。
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**注意**：以上文献信息为示例性质，实际引用时请通过PubMed或Google Scholar核对作者、标题及摘要准确性。如需具体文献，可进一步提供研究方向或PMID编号。
RASA2 antibody is a research tool designed to detect and study the RASA2 protein, a member of the RAS p21 protein activator (GAP) family. RASA2. encoded by the *RASA2* gene, acts as a negative regulator of the RAS signaling pathway by accelerating the hydrolysis of active GTP-bound RAS to its inactive GDP-bound state. This regulatory role positions RASA2 as a critical player in controlling cellular processes such as proliferation, differentiation, and survival. Dysregulation of RAS signaling, often linked to mutations in RAS or its regulators, is implicated in cancers and developmental disorders.
RASA2 contains conserved structural domains, including a PH domain for membrane targeting and a GAP domain for RAS interaction. Studies suggest its involvement in immune cell function, vascular development, and tumor suppression. For instance, reduced RASA2 expression has been observed in certain cancers, potentially contributing to RAS-driven oncogenesis. Antibodies targeting RASA2 enable researchers to investigate its expression patterns, subcellular localization, and interactions in various tissues or disease models. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence.
Recent research highlights RASA2's role in modulating therapeutic responses, such as in melanoma and leukemia, where its loss may influence drug resistance. The antibody thus serves as a vital reagent for unraveling RASA2's biological functions and its implications in disease mechanisms, offering insights for potential therapeutic targeting.
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