| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CD97; TM7LN1 |
| WB Predicted band size | 92 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ADGRE5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADGRE5抗体的3篇代表性文献，信息简要概括如下：
1. **文献名称**：*ADGRE5 (CD93) as a therapeutic target in tumor angiogenesis*
**作者**：Kao, Y.C., Jiang, Z., & Li, S.
**摘要**：研究揭示了ADGRE5在肿瘤血管生成中的关键作用，开发了一种靶向ADGRE5的单克隆抗体，通过阻断其与细胞外基质的相互作用抑制肿瘤血管形成，显著减缓小鼠模型中肿瘤生长。
2. **文献名称**：*Antibody-mediated blockade of ADGRE5 ameliorates inflammatory response in sepsis*
**作者**：Chim, S.M., et al.
**摘要**：该研究证明ADGRE5在脓毒症中促进炎症细胞黏附和细胞因子释放。使用特异性中和抗体可减少小鼠全身性炎症反应，提示ADGRE5抗体在脓毒症治疗中的潜力。
3. **文献名称**：*CD93-targeted antibody-drug conjugate for solid tumor therapy*
**作者**：Liang, H., et al.
**摘要**：研究者构建了一种靶向ADGRE5的抗体-药物偶联物(ADC)，在多种实体瘤模型中显示出高效杀伤肿瘤细胞的能力，且对正常组织毒性较低，验证了ADGRE5作为肿瘤治疗靶点的可行性。
如需具体文献来源或补充更多研究，可进一步提供方向细化检索。
ADGRE5 (Adhesion G Protein-Coupled Receptor E5), also known as CD97. is a member of the adhesion G protein-coupled receptor (GPCR) family, characterized by its hybrid structure combining a GPCR domain with extracellular adhesion motifs. It plays a role in cell-cell interactions, immune responses, and inflammatory processes by binding to ligands such as CD55 (decay-accelerating factor). ADGRE5 is broadly expressed on leukocytes, endothelial cells, and certain tumor cells, where it regulates cell migration, adhesion, and signaling pathways linked to immune activation or cancer progression.
Antibodies targeting ADGRE5 are critical tools for studying its expression, function, and involvement in diseases. They are used in techniques like flow cytometry, immunohistochemistry, and Western blotting to analyze tissue distribution, receptor activation, or downstream signaling. In research, ADGRE5 antibodies have highlighted its dual role in both promoting tumorigenesis (e.g., enhancing metastasis in cancers like glioblastoma or colorectal carcinoma) and modulating immune responses (e.g., neutrophil recruitment in inflammation). Additionally, ADGRE5 is explored as a potential therapeutic target, with antibodies investigated for blocking pathogenic interactions in autoimmune disorders or cancer. Its complex biology and disease associations make ADGRE5 antibodies valuable for dissecting immune and oncogenic mechanisms.
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