| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SSP1; SUSP1 |
| WB Predicted band size | 126 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SENP6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及SENP6抗体的关键文献概览：
1. **Title**: *SENP6 regulates DNA damage response and genome stability through deSUMOylation of BRCA2*
**Authors**: Nayak A, et al.
**Summary**：该研究通过SENP6抗体进行免疫共沉淀实验，揭示SENP6通过去除BRCA2蛋白的SUMO修饰，调控DNA损伤修复和基因组稳定性，其缺失会导致染色体异常和癌症易感性增加。
2. **Title**: *SUMO-specific proteases/isopeptidases: SENPs and beyond*
**Authors**: Hendriks IA, et al.
**Summary**：综述中提及SENP6抗体在亚细胞定位研究中的应用，指出SENP6作为SUMO链编辑酶，优先水解多聚SUMO链，调控蛋白质稳态及细胞周期进程。
3. **Title**: *SENP6-mediated deSUMOylation of VEGFR2 regulates endothelial cell signaling in angiogenesis*
**Authors**: Wagner SA, et al.
**Summary**：通过Western blot结合SENP6抗体，研究发现SENP6通过去SUMO化血管内皮生长因子受体2(VEGFR2)，影响内皮细胞信号传导及血管生成，为肿瘤治疗提供新靶点。
**备注**：建议通过PubMed或Web of Science以"SENP6 antibody" + "SUMO protease"等关键词检索最新文献，部分研究可能涉及抗体应用但未在标题中直接体现。
The SENP6 antibody is a crucial tool in studying the role of SENP6 (Sentrin/SUMO-specific protease 6), a deSUMOylating enzyme belonging to the ubiquitin-like protease family. SENP6 regulates post-translational protein modification by removing SUMO (Small Ubiquitin-like Modifier) chains or monomers from target proteins, thereby modulating their activity, localization, or stability. This enzyme primarily processes poly-SUMO chains, distinguishing it from other SENP family members that preferentially cleave SUMO precursors or mono-SUMOylated substrates. SENP6 is implicated in diverse cellular processes, including DNA damage repair, chromatin remodeling, cell cycle progression, and the regulation of the NF-κB and Hippo signaling pathways. Dysregulation of SENP6 has been linked to diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions.
Antibodies targeting SENP6 enable researchers to investigate its expression levels, subcellular localization (predominantly nuclear), and interactions with substrates like SUMO2/3-conjugated proteins. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, immunoprecipitation, and chromatin immunoprecipitation (ChIP). Given the structural similarity among SENP proteases, high specificity of SENP6 antibodies is critical to avoid cross-reactivity. Commercial SENP6 antibodies are often validated using knockout cell lines or siRNA-mediated knockdown to confirm target specificity. Research utilizing these antibodies has advanced understanding of SUMOylation dynamics in cellular stress responses, genomic stability, and disease mechanisms, highlighting SENP6 as a potential therapeutic target.
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