| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SCP2; SCP-2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SYCP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SYCP2抗体的3篇参考文献的简要概括：
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1. **文献名称**: *SYCP2 is a component of the synaptonemal complex and interacts with SYCP1 in meiosis*
**作者**: Hamer, G., et al.
**摘要**: 该研究揭示了SYCP2在减数分裂联会复合体(SC)中的关键作用，证明其与SYCP1的相互作用对染色体配对和重组至关重要。通过抗体标记实验，发现SYCP2缺失会导致小鼠生殖细胞减数分裂异常及不育。
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2. **文献名称**: *SYCP2 links meiosis initiation to centrosome dynamics in male germ cells*
**作者**: Yang, F., et al.
**摘要**: 本文利用SYCP2特异性抗体研究其在雄性生殖细胞减数分裂启动中的作用，发现SYCP2通过调控中心体动力学影响纺锤体形成，其异常表达与人类非梗阻性无精症(NOA)相关。
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3. **文献名称**: *SYCP2 is a potential biomarker for hepatocellular carcinoma progression*
**作者**: Zhang, J., et al.
**摘要**: 该研究通过免疫组化分析发现，SYCP2在肝癌组织中高表达，并与肿瘤分期和患者预后显著相关。SYCP2抗体检测提示其可能作为肝癌早期诊断或治疗靶点的潜在价值。
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**备注**：上述文献为虚拟示例，实际引用时需通过PubMed或Google Scholar检索真实文献(如搜索关键词"SYCP2 antibody function"或"SYCP2 meiosis/cancer")。
The SYCP2 antibody targets the synaptonemal complex protein 2 (SYCP2), a key component of the synaptonemal complex (SC) essential for meiosis in eukaryotic cells. SYCP2. along with SYCP3. forms the lateral elements of the SC, a proteinaceous structure that mediates homologous chromosome pairing, recombination, and segregation during gametogenesis. SYCP2 is critical for SC assembly, stabilization, and the regulation of crossover formation. It interacts with other meiotic proteins, such as cohesins and recombination mediators, ensuring proper chromosomal synapsis and genomic integrity.
Research involving SYCP2 antibodies primarily focuses on studying meiotic processes, fertility disorders, and germ cell development. These antibodies are widely used in techniques like immunofluorescence, Western blotting, and immunohistochemistry to visualize SYCP2 localization during meiotic prophase I, particularly in spermatocytes and oocytes. Abnormalities in SYCP2 expression or function have been linked to meiotic arrest, non-obstructive azoospermia, and recurrent pregnancy loss, making it a biomarker of interest in reproductive medicine. Additionally, SYCP2 antibodies aid in exploring the molecular mechanisms of SC dynamics and their implications in aneuploidy or developmental defects. Commercial SYCP2 antibodies are typically validated in model organisms (e.g., mice, humans) to support both basic and clinical research in reproductive biology.
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