| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SH3D6A; dJ323M4.1 |
| WB Predicted band size | 137 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SASH1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SASH1抗体的3-4篇参考文献示例(文献信息为虚构，仅供格式参考)：
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1. **文献名称**：*SASH1 Antibody Validation in Tumor Suppression Studies*
**作者**：Smith A, et al.
**摘要**：本研究利用SASH1特异性抗体进行免疫印迹和免疫组化，证实SASH1在乳腺癌组织中表达下调，并通过调控MAPK通路抑制肿瘤生长。
2. **文献名称**：*SASH1 Expression Correlates with Melanoma Progression*
**作者**：Brown K, et al.
**摘要**：通过SASH1抗体标记的免疫荧光和流式细胞术，发现SASH1低表达与黑色素瘤转移相关，提示其作为治疗靶点的潜力。
3. **文献名称**：*Development of a High-Affinity SASH1 Monoclonal Antibody for Diagnostic Applications*
**作者**：Lee J, et al.
**摘要**：报道了一种新型SASH1单克隆抗体的开发，验证了其在ELISA和免疫沉淀中的高特异性，适用于癌症早期诊断研究。
4. **文献名称**：*SASH1 Regulates Oxidative Stress in Hepatocellular Carcinoma*
**作者**：Garcia R, et al.
**摘要**：采用SASH1抗体进行组织芯片分析，发现SASH1通过抑制ROS积累延缓肝癌进展，为抗氧化治疗提供新思路。
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**注**：以上文献为示例，实际引用时需通过PubMed、Web of Science等数据库检索真实存在的论文。
The SASH1 (SAM and SH3 domain-containing protein 1) antibody is a crucial tool for studying the role of the SASH1 protein, encoded by the tumor suppressor gene *SASH1*. SASH1 is implicated in regulating cellular processes such as apoptosis, signal transduction, and cell adhesion. It is widely expressed in normal tissues, including the immune system, brain, and epithelial cells. Research highlights its downregulation in various cancers (e.g., breast, colorectal, and lung cancers), correlating with tumor progression, metastasis, and poor prognosis. SASH1’s tumor-suppressive functions involve inhibiting proliferation, migration, and invasion, often through pathways like PI3K/AKT and NF-κB.
The SASH1 antibody enables the detection and quantification of SASH1 protein levels in experimental models, facilitating investigations into its expression patterns, subcellular localization (primarily cytoplasmic), and interactions with signaling molecules. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Validating antibody specificity is critical, often achieved via knockout controls or siRNA knockdown. Clinically, SASH1 expression is being explored as a potential biomarker for cancer diagnosis or prognosis. Additionally, studies link SASH1 mutations to genetic disorders like dyschromatosis symmetrica hereditaria, underscoring its diverse biological roles beyond oncology. This antibody thus serves as a vital reagent in both cancer research and genetic disease studies.
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