| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| WB Predicted band size | 71 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SRP68 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SRP68抗体的3篇概括性参考文献示例(注：以下内容为模拟概括，具体文献需通过学术数据库查询)：
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1. **文献名称**：*SRP68 mutations in congenital neutropenia: functional characterization and antibody-based detection*
**作者**：Smith A, et al.
**摘要**：本研究揭示了SRP68基因突变与先天性中性粒细胞减少症的关系，开发了特异性SRP68抗体用于患者样本中突变蛋白的免疫印迹检测，证实突变导致SRP复合体功能异常，影响蛋白质转运。
2. **文献名称**：*Structural insights into the SRP68-SRP72 heterodimer using cryo-EM and monoclonal antibody labeling*
**作者**：Chen L, et al.
**摘要**：通过冷冻电镜技术解析SRP68与其结合蛋白SRP72的复合物结构，利用单克隆抗体标记关键表位，阐明二者在信号肽识别中的协同作用，为SRP组装机制提供分子基础。
3. **文献名称**：*Development of a high-affinity SRP68 antibody for diagnostic applications in autoimmune diseases*
**作者**：Wang Y, et al.
**摘要**：报道一种新型兔源多克隆SRP68抗体的制备与验证，该抗体在ELISA和免疫组化中表现出高特异性，可用于自身免疫病患者血清中抗SRP抗体的筛查，具有潜在临床诊断价值。
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**提示**：以上为模拟摘要，实际文献请通过PubMed、Google Scholar等平台以“SRP68 antibody”或“SRP68 AND (function/disease)”为关键词检索。
The SRP68 antibody is a research tool designed to detect and study the Signal Recognition Particle 68 kDa (SRP68) protein, a critical component of the eukaryotic signal recognition particle (SRP). The SRP is a ribonucleoprotein complex essential for co-translational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP68. along with SRP72. forms a heterodimer that binds to SRP RNA, stabilizing the complex and facilitating its interaction with ribosomes and signal sequences on nascent polypeptides.
Antibodies against SRP68 are widely used in molecular and cellular biology to investigate SRP assembly, protein translocation mechanisms, and SRP-related pathologies. They enable techniques like Western blotting, immunofluorescence, and immunoprecipitation to analyze SRP68 expression, localization, and interactions. Dysregulation of SRP68 has been implicated in rare genetic disorders, such as congenital neutropenia, where mutations disrupt SRP function, leading to impaired protein synthesis and hematopoietic defects.
These antibodies are also valuable in studying cellular stress responses, as ER-targeting defects can trigger unfolded protein responses. Researchers utilize SRP68 antibodies across model organisms, including humans, mice, and rats, to explore conserved roles in gene expression regulation and disease mechanisms. Commercial variants are typically validated for specificity, often through knockout cell lines, ensuring reliability in experimental applications.
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