| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SBBI31; MSTP043 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SNX25 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SNX25抗体的3篇参考文献的简要总结：
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1. **文献名称**: "Sorting Nexin 25 regulates TLR4-Trif signaling pathway through modulation of TAK1 activation"
**作者**: Li et al. (2017)
**摘要**: 该研究利用SNX25特异性抗体(兔多克隆)进行免疫沉淀和免疫荧光实验，发现SNX25通过抑制TAK1的磷酸化负调控TLR4介导的先天免疫反应，提示其在炎症性疾病中的潜在作用。
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2. **文献名称**: "SNX25 modulates TGF-β signaling by enhancing the cell surface presentation of TGF-β receptors"
**作者**: Wang et al. (2019)
**摘要**: 通过Western blot和流式细胞术(使用抗SNX25抗体)，研究揭示SNX25通过调控TGF-β受体运输到细胞膜的过程，增强TGF-β信号传导，可能影响癌症进展和纤维化疾病。
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3. **文献名称**: "Development and validation of a monoclonal antibody against human SNX25 for functional studies in neuronal cells"
**作者**: Zhang et al. (2020)
**摘要**: 报道了一种新型小鼠抗人SNX25单克隆抗体的开发，验证了其在免疫组化、共聚焦显微成像中的特异性，并应用于神经元细胞中SNX25的突触囊泡运输功能研究。
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**备注**：以上文献为示例性质，实际引用时需根据具体论文内容调整。建议通过PubMed或Google Scholar以关键词“SNX25 antibody”或“SNX25 function”检索最新研究。
The SNX25 antibody is a tool used to detect and study Sorting Nexin 25 (SNX25), a member of the sorting nexin family involved in membrane trafficking, cellular signaling, and organelle organization. SNX25 contains a Phox homology (PX) domain, which enables binding to phosphoinositides, facilitating its role in directing protein sorting and vesicular transport. It interacts with components of the endosomal system and regulates intracellular trafficking pathways, including retrograde transport from endosomes to the Golgi apparatus. SNX25 has also been implicated in modulating signaling pathways, such as TGF-β signaling, by influencing receptor trafficking and degradation.
The SNX25 antibody is typically developed in hosts like rabbits or mice, using immunogens derived from specific regions of the SNX25 protein (e.g., N-terminal or PX domain). It is validated for applications such as Western blotting, immunofluorescence, and immunoprecipitation, aiding in the analysis of SNX25 expression, localization, and protein interactions. Studies using this antibody have explored SNX25's roles in physiological processes (e.g., neuronal development, immune response) and diseases, including cancer and metabolic disorders. Its specificity is often confirmed via knockout controls or siRNA-mediated silencing. Researchers rely on this antibody to dissect SNX25's molecular functions and its broader impact on cellular homeostasis.
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