| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | KLIP; ABIN2; FLIP1 |
| WB Predicted band size | 49 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human TNIP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及TNIP2抗体的参考文献摘要，信息基于公开文献概括：
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1. **文献名称**: *TNIP2 interacts with TRAF2 to regulate the NF-κB signaling pathway in inflammation*
**作者**: Li X, et al.
**摘要**: 该研究通过免疫共沉淀(Co-IP)结合TNIP2特异性抗体，发现TNIP2通过与TRAF2相互作用负调控NF-κB信号通路，抑制炎症反应。Western blot和免疫荧光实验证实TNIP2在炎症条件下表达上调。
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2. **文献名称**: *Aberrant TNIP2 expression in psoriasis skin and its role in keratinocyte proliferation*
**作者**: Wang Y, et al.
**摘要**: 利用TNIP2多克隆抗体进行免疫组化分析，发现银屑病皮损中TNIP2蛋白表达显著降低。体外实验表明，TNIP2通过抑制ERK通路减少角质形成细胞过度增殖，提示其作为银屑病潜在治疗靶点。
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3. **文献名称**: *Development and validation of a TNIP2-specific monoclonal antibody for cancer biomarker studies*
**作者**: Chen H, et al.
**摘要**: 本研究报道了一种新型TNIP2单克隆抗体的开发，并通过ELISA、流式细胞术验证其特异性。该抗体成功应用于乳腺癌组织微阵列分析，显示TNIP2低表达与患者不良预后相关。
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注：以上文献信息为示例性质，实际文献需通过PubMed或Web of Science等平台检索确认。
TNIP2 (TNFAIP3-interacting protein 2), also known as ABIN2. is a ubiquitin-binding adaptor protein that plays a critical role in regulating NF-κB signaling pathways, inflammation, and apoptosis. It interacts with TNFAIP3 (A20), a key deubiquitinating enzyme, to inhibit NF-κB activation by modulating the ubiquitination status of signaling intermediates like RIPK1 and TRAF6. TNIP2 contains a ubiquitin-binding domain (UBAN) that enables its participation in protein-protein interactions and immune response regulation. Dysregulation of TNIP2 has been implicated in autoimmune diseases, cancers, and inflammatory disorders. For example, reduced TNIP2 expression correlates with increased NF-κB activity in certain cancers, suggesting a tumor-suppressive role.
TNIP2 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques such as Western blotting, immunohistochemistry, and co-immunoprecipitation to explore TNIP2's function in cellular models or clinical samples. Commercially available TNIP2 antibodies are typically validated for specificity against human, mouse, or rat isoforms. Research using these antibodies has highlighted TNIP2's involvement in diseases like lupus, psoriasis, and lymphoma, as well as its role in modulating drug resistance in cancer therapy. Reliable TNIP2 antibodies are critical for advancing mechanistic studies and potential therapeutic targeting of TNIP2-associated pathways.
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