| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| WB Predicted band size | 72 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human TNK1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TNK1抗体的3篇示例文献(注意：以下为模拟示例，实际文献需通过学术数据库查询)：
1. **文献名称**：*TNK1 Kinase Function in Cancer Cell Signaling*
**作者**：Smith A, et al.
**摘要**：研究探讨了TNK1酪氨酸激酶在肿瘤细胞中的调控机制，通过特异性抗体检测其在乳腺癌中的异常表达，揭示其促进肿瘤增殖的潜在作用。
2. **文献名称**：*Development of a Monoclonal Antibody Targeting TNK1 for Therapeutic Applications*
**作者**：Wang L, et al.
**摘要**：报道了一种新型抗TNK1单克隆抗体的开发与验证，证明其在体外可抑制TNK1活性，并可能作为针对血液系统恶性肿瘤的治疗工具。
3. **文献名称**：*TNK1 Interacts with STAT3 and Modulates Inflammatory Signaling*
**作者**：Johnson R, et al.
**摘要**：利用免疫共沉淀(Co-IP)和Western blot技术，结合TNK1抗体发现其与STAT3的相互作用，提示其在炎症相关信号通路中的调控功能。
建议通过PubMed、Google Scholar或Sci-Hub等平台，以“TNK1 antibody”、“TNK1 kinase”等关键词检索最新文献。
**Background of TNK1 Antibody**
The TNK1 (Tyrosine Kinase Non-Receptor 1) gene encodes a non-receptor tyrosine kinase implicated in cellular signaling pathways regulating proliferation, survival, and cytoskeletal dynamics. Discovered in the late 1990s, TNK1 belongs to the ACK (Activated Cdc42-associated kinase) family and contains an SH3 domain, a kinase domain, and a conserved C-terminal region. Unlike many kinases, TNK1 lacks canonical regulatory domains, relying instead on autophosphorylation and interactions with partners like HSP90 or 14-3-3 proteins for activation and stability.
TNK1 antibodies are critical tools for studying its expression, localization, and function. These antibodies are designed to detect TNK1 in techniques such as Western blotting, immunoprecipitation, or immunofluorescence. Research suggests TNK1 is overexpressed in certain cancers, including leukemia and solid tumors, where it may drive oncogenic signaling or chemoresistance. Antibodies help validate TNK1 as a biomarker or therapeutic target.
However, TNK1’s low basal expression in normal tissues and technical challenges in distinguishing it from homologous kinases (e.g., TNK2/ACK1) necessitate highly specific antibodies. Recent studies also link TNK1 to neurodegenerative diseases, expanding its research scope. Commercial TNK1 antibodies are typically polyclonal or monoclonal, validated for selectivity across human and model organisms. Ongoing work aims to clarify TNK1’s dual roles in cancer and neurology, leveraging antibodies to explore its mechanistic and therapeutic potential.
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