| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ZNF200 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZNF200抗体的3篇示例参考文献(注：以下内容为模拟生成，实际文献需通过学术数据库查询)：
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1. **文献名称**：*ZNF200 Antibody Production and Its Expression in Human Tissues*
**作者**：Zhang L, et al.
**摘要**：该研究通过重组ZNF200蛋白免疫动物制备了多克隆抗体，验证了其在Western blot和免疫组化中的特异性，并发现ZNF200在神经组织和生殖系统中高表达，提示其潜在生物学功能。
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2. **文献名称**：*Role of ZNF200 in Epigenetic Regulation: Insights from Antibody-Based Knockdown Assays*
**作者**：Wang Y, et al.
**摘要**：利用ZNF200抗体进行染色质免疫沉淀(ChIP)分析，发现ZNF200通过与组蛋白修饰酶相互作用参与基因沉默，为肿瘤表观遗传调控机制提供了新证据。
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3. **文献名称**：*ZNF200 Autoantibodies as a Biomarker in Autoimmune Diseases*
**作者**：Chen X, et al.
**摘要**：首次报道ZNF200抗体在系统性红斑狼疮(SLE)患者血清中异常升高，提示其可能作为自身免疫反应的潜在生物标志物，并探讨了其与疾病活动的相关性。
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如需具体文献，建议通过PubMed、Google Scholar等平台以“ZNF200 antibody”或“ZNF200 autoantibody”为关键词检索。
The ZNF200 antibody is a tool used to detect and study the zinc finger protein 200 (ZNF200), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein (ZNF) family. ZNF200. encoded by the human ZNF200 gene, is characterized by its N-terminal KRAB domain and multiple C-terminal C2H2-type zinc finger motifs, which are critical for DNA binding and protein-protein interactions. As a transcription regulator, ZNF200 is implicated in chromatin remodeling and transcriptional repression, potentially through interactions with histone deacetylases (HDACs) or other chromatin-modifying complexes. Its expression has been observed in various tissues, though functional studies remain limited compared to other ZNF proteins.
Research involving ZNF200 antibodies primarily focuses on elucidating its role in cellular processes, including differentiation, apoptosis, and tumor suppression. Some studies suggest ZNF200 may act as a tumor suppressor in certain cancers, such as leukemia, by modulating oncogenic pathways. Additionally, its potential involvement in neurodegenerative diseases, like Parkinson’s, has been explored due to links with oxidative stress responses. The antibody is commonly utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression levels, subcellular localization, and interaction partners.
Despite its utility, challenges persist in specificity and availability of high-quality ZNF200 antibodies, partly due to the protein’s low abundance and structural homology with other ZNF family members. Ongoing research aims to clarify its mechanistic roles and therapeutic relevance.
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