Rabbit Polyclonal XKR4 Antibody

The XKR4 antibody targets the XKR4 protein, a member of the XK-related (XKR) family, which is implicated in phospholipid scrambling and apoptotic signaling. XKR proteins are transmembrane molecules involved in phosphatidylserine (PS) exposure on cell surfaces—a hallmark of apoptosis that triggers phagocytic clearance. While XKR4’s exact biological role remains under investigation, studies suggest it may function as a phospholipid scramblase, facilitating PS redistribution during programmed cell death. It shares structural homology with other XKR members, such as XKR8 and XKR9. which are known to regulate cell death in specific tissues. XKR4 is expressed in various organs, including the brain, testes, and immune tissues, hinting at tissue-specific roles in apoptosis or immune modulation. Research on XKR4 antibodies primarily focuses on elucidating its physiological functions, interaction partners, and potential links to diseases like cancer or neurodegenerative disorders. These antibodies are critical tools for detecting XKR4 expression via techniques like Western blotting, immunofluorescence, or flow cytometry. Recent studies also explore XKR4’s involvement in spermatogenesis and neuronal survival, though mechanistic insights are still emerging. Overall, XKR4 antibodies serve as key reagents in decoding the protein’s contributions to cellular homeostasis and pathology.