| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | OODD; SSPS; STHAG4 |
| WB Predicted band size | 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human WNT10A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于WNT10A抗体的3篇示例文献(注：文献为虚构示例，仅作格式参考，实际引用需查阅真实数据库)：
1. **文献名称**：*WNT10A Antibody Validation in Odontogenesis Studies*
**作者**：Adaimy L., et al.
**摘要**：本研究利用兔源多克隆WNT10A抗体，通过免疫组化技术检测其在牙胚发育中的表达模式，证实了WNT10A在成牙本质细胞分化中的关键作用。
2. **文献名称**：*Role of WNT10A in Cutaneous Squamous Cell Carcinoma: An Immunohistochemical Analysis*
**作者**：Bohórquez M., et al.
**摘要**：通过商业化小鼠单克隆WNT10A抗体进行免疫组织化学染色，发现WNT10A在皮肤鳞状细胞癌中高表达，提示其可能参与肿瘤侵袭性调控。
3. **文献名称**：*Development of a High-Specificity WNT10A Monoclonal Antibody for Western Blot Applications*
**作者**：Niemann C., et al.
**摘要**：报道了一种新型抗人WNT10A单克隆抗体的开发与验证，该抗体在Western blot和免疫荧光中表现出高特异性，适用于干细胞再生研究中的蛋白检测。
建议通过PubMed或Google Scholar搜索关键词“WNT10A antibody” + “validation/IHC/Western”获取真实文献。
**Background of WNT10A Antibody**
WNT10A is a secreted glycoprotein belonging to the Wnt family, which plays critical roles in embryonic development, tissue homeostasis, and stem cell regulation by activating the Wnt/β-catenin signaling pathway. It is particularly essential for the development of ectodermal appendages (e.g., teeth, hair, nails) and skeletal structures. Mutations in the *WNT10A* gene are linked to human disorders such as odonto-onycho-dermal dysplasia (OODD), Schöpf-Schulz-Passarge syndrome, and severe tooth agenesis.
WNT10A antibodies are immunological tools designed to detect and study the expression, localization, and function of the WNT10A protein. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA to investigate Wnt signaling dynamics in developmental biology, cancer research (e.g., tumorigenesis, metastasis), and regenerative medicine. Both monoclonal and polyclonal WNT10A antibodies are available, with specificity validated across species (human, mouse, rat).
Research utilizing WNT10A antibodies has advanced understanding of its role in tissue-specific stem cell niches, crosstalk with other signaling pathways (e.g., FGF, BMP), and potential therapeutic targets for genetic or degenerative diseases. However, challenges remain due to the complexity of Wnt ligand-receptor interactions and post-translational modifications influencing antibody binding efficiency.
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