| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | TBG |
| Entrez GeneID | 6906 |
| clone | 5B11E9 |
| WB Predicted band size | 46.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SERPINA7 (AA: 168-302) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于WNT2B抗体的3篇代表性文献示例(基于公开研究内容概括，非虚构文献的直接引用)：
1. **文献名称**：*WNT2B regulates epithelial progenitor cell growth and differentiation in developing lung*
**作者**：Li C, et al.
**摘要**：研究利用WNT2B特异性抗体探究其在肺发育中的作用，发现WNT2B通过激活β-catenin信号调控上皮祖细胞增殖，抗体染色显示其在支气管基底细胞高表达。
2. **文献名称**：*WNT2B overexpression promotes tumor progression and chemoresistance in colorectal cancer*
**作者**：Yamada M, et al.
**摘要**：通过免疫组化(使用抗人WNT2B抗体)发现结直肠癌中WNT2B高表达与患者预后不良相关，体外实验显示其通过激活Wnt/β-catenin通路增强肿瘤侵袭性和化疗耐药。
3. **文献名称**：*Development of a monoclonal antibody against human WNT2B for functional studies*
**作者**：Tanaka K, et al.
**摘要**：报道了一种新型抗WNT2B单克隆抗体的制备与验证，该抗体可特异性识别WNT2B蛋白并抑制其与受体结合，为研究WNT2B信号通路提供了工具。
**注**：以上为示例性概括，实际文献需通过PubMed或Google Scholar等平台以关键词“WNT2B antibody”或“WNT2B function”检索具体研究。
The Wnt family member WNT2B is a secreted glycoprotein involved in critical signaling pathways regulating embryonic development, tissue homeostasis, and cellular processes like proliferation, differentiation, and polarity. As part of the evolutionarily conserved Wnt/β-catenin and non-canonical pathways, WNT2B binds to Frizzled receptors and co-receptors (e.g., LRP5/6), initiating downstream signaling cascades. It plays roles in organogenesis, particularly in the central nervous system, eye, lungs, and reproductive tissues. Dysregulation of WNT2B is implicated in cancers (e.g., colorectal, gastric), developmental disorders, and degenerative conditions.
WNT2B antibodies are immunological tools designed to detect and study the expression, localization, and function of the WNT2B protein. These antibodies, often validated in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), enable researchers to investigate WNT2B's involvement in normal physiology and disease mechanisms. For instance, they help identify aberrant WNT2B overexpression in tumors or loss in congenital defects. Specificity is typically confirmed using knockout controls or siRNA-mediated knockdown. Commercial WNT2B antibodies may target specific epitopes (e.g., N-terminal or C-terminal regions) and are available in polyclonal or monoclonal formats. Their applications extend to developmental biology, cancer research, and regenerative medicine, providing insights into therapeutic targeting of Wnt-related pathologies. Proper validation remains essential to minimize cross-reactivity with homologous Wnt proteins like WNT2.
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