| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TAP; Sca1; Sca-1; Ly-6A.2; Ly-6A/E; Ly-6E.1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of mouse Ly6a |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SYNCRIP抗体的3篇参考文献示例(文献信息为示例，建议通过学术数据库核实具体内容)：
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1. **文献名称**: *SYNCRIP regulates hepatitis C virus RNA replication by interacting with the viral NS5B protein*
**作者**: Masaki, T., et al. (2013)
**摘要**: 该研究利用SYNCRIP抗体进行免疫共沉淀实验，发现SYNCRIP蛋白通过与HCV非结构蛋白NS5B结合，促进病毒RNA的复制，揭示了其在丙型肝炎病毒生命周期中的关键作用。
2. **文献名称**: *SYNCRIP modulates pluripotency and differentiation of embryonic stem cells via mRNA stability control*
**作者**: Climente-Garcia, J.R., et al. (2017)
**摘要**: 通过SYNCRIP抗体的Western blot和免疫荧光分析，研究发现SYNCRIP通过调控多能性相关mRNA(如Oct4、Nanog)的稳定性，维持胚胎干细胞的自我更新能力。
3. **文献名称**: *SYNCRIP promotes tumor metastasis by enhancing the translation of EMT-related transcripts*
**作者**: Chen, L., et al. (2020)
**摘要**: 该研究使用SYNCRIP抗体进行组织芯片分析，发现SYNCRIP在多种癌症中高表达，并通过结合上皮间质转化(EMT)相关mRNA(如Snail、Twist1)，促进肿瘤细胞的侵袭和转移。
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**提示**：实际文献需通过PubMed、Web of Science或Google Scholar等平台，以“SYNCRIP antibody”及研究领域(如病毒、癌症、干细胞)为关键词检索。部分真实研究可能涉及SYNCRIP在RNA结合、神经功能或肿瘤微环境中的作用。
**Background of SYNCRIP Antibody**
SYNCRIP (Synaptotagmin Binding Cytoplasmic RNA Interacting Protein), also known as hnRNP-Q or NSAP1. is a multifunctional RNA-binding protein encoded by the *SYNCRIP* gene. It belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family and plays critical roles in RNA metabolism, including splicing, transport, stability, and translation regulation. Structurally, SYNCRIP contains RNA recognition motifs (RRMs) and a prion-like domain, enabling interactions with diverse RNA targets and proteins.
SYNCRIP antibodies are essential tools for studying its involvement in cellular processes such as viral replication (e.g., hepatitis C virus), neurodevelopment, and cancer progression. Research highlights its dual role in malignancies—acting as a tumor suppressor in some contexts (e.g., inhibiting Wnt/β-catenin signaling) or an oncogene in others (e.g., enhancing melanoma metastasis). Additionally, SYNCRIP regulates neuronal mRNA localization and synaptic plasticity, linking it to neurological disorders.
Antibodies targeting SYNCRIP enable detection and functional analysis via techniques like Western blot, immunofluorescence, and immunoprecipitation. Their development has advanced understanding of SYNCRIP's dynamic interactions with RNA-protein complexes, offering insights into therapeutic targeting for diseases like cancer and neurodegenerative conditions.
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