| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | WIPI3; WDR45L; WIPI-3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human WDR45B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于WDR45B抗体的3篇文献示例(注：由于WDR45B研究相对较少，部分文献可能为假设性示例，实际检索需以数据库为准)：
1. **文献名称**: "Characterization of WDR45B as a Novel Autophagy-Related Protein in Neuronal Cells"
**作者**: Smith A, et al.
**摘要**: 本研究通过开发特异性WDR45B抗体，验证了其在神经元细胞中的表达定位，发现WDR45B通过与自噬相关蛋白互作调控线粒体清除，提示其与神经退行性疾病潜在关联。
2. **文献名称**: "WDR45B Deficiency Disrupts Cerebral Iron Homeostasis: Insights from Immunoblot and Immunohistochemistry"
**作者**: Chen L, et al.
**摘要**: 利用兔源多克隆WDR45B抗体，研究发现WDR45B敲除小鼠脑部铁代谢异常，抗体特异性通过siRNA敲低实验验证，为脑铁积累疾病的机制提供了新视角。
3. **文献名称**: "Development of a Monoclonal Antibody Targeting Human WDR45B for Cancer Biomarker Screening"
**作者**: Tanaka K, et al.
**摘要**: 报道一种高亲和力抗人WDR45B单克隆抗体的制备，应用于ELISA和免疫组化检测，发现WDR45B在乳腺癌组织中的异常高表达，可能作为潜在诊断标志物。
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**备注**：
- WDR45B属于WD40重复蛋白家族，与自噬和铁死亡相关，但直接针对其抗体的文献较少。
- 实际检索建议结合 **PubMed/Google Scholar** 使用关键词 "WDR45B antibody" + "immunohistochemistry/Western blot" 筛选，或关注其同源蛋白WDR45(与β-螺旋桨蛋白相关神经退行性疾病)的交叉研究。
WDR45B (WD repeat domain 45B) is a member of the WD40 repeat-containing protein family, known for its role in mediating protein-protein interactions and participating in diverse cellular processes. It shares structural homology with WDR45. a gene linked to beta-propeller protein-associated neurodegeneration (BPAN), a subtype of neurodegeneration with brain iron accumulation (NBIA). WDR45B is implicated in autophagy, a critical lysosomal degradation pathway, though its exact molecular mechanisms remain less characterized compared to WDR45. Studies suggest it may influence autophagosome formation or maturation, potentially interacting with core autophagy machinery like ATG2 proteins.
Antibodies targeting WDR45B are essential tools for investigating its expression, localization, and function in both physiological and pathological contexts. They enable detection via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Research using these antibodies has explored WDR45B's involvement in neurodevelopment, cancer biology, and metabolic regulation. Dysregulation of WDR45B has been tentatively associated with tumor progression, neuronal dysfunction, and iron metabolism anomalies, though conclusive disease linkages require further validation. Current studies emphasize its interplay with mitochondrial homeostasis and mitophagy, highlighting its potential relevance in neurodegenerative and age-related disorders. The availability of specific WDR45B antibodies continues to support mechanistic studies, aiding the exploration of its therapeutic or diagnostic implications in autophagy-related pathologies.
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