| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IRP; INT1L1 |
| WB Predicted band size | 40 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human WNT2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与WNT2抗体相关的文献概述(文献标题与作者为虚构示例，供参考格式)：
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1. **标题**: *WNT2 overexpression promotes gastric cancer progression through β-catenin stabilization*
**作者**: Zhang et al. (2018)
**摘要**: 研究通过免疫组化(IHC)和Western blot分析胃癌组织中WNT2蛋白表达，发现WNT2抗体检测显示其在肿瘤组织中显著上调，并通过激活Wnt/β-catenin通路促进癌细胞侵袭。
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2. **标题**: *WNT2-mediated fibroblast activation drives pulmonary fibrosis*
**作者**: Li et al. (2020)
**摘要**: 利用WNT2特异性抗体进行肺组织染色，证实WNT2在纤维化区域高表达，并证明其通过调控成纤维细胞分化导致肺纤维化进展，抗体阻断实验可减轻小鼠模型纤维化程度。
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3. **标题**: *WNT2 as a biomarker for colorectal cancer stem cells*
**作者**: Smith et al. (2017)
**摘要**: 研究通过流式细胞术和免疫荧光染色(使用抗人WNT2单克隆抗体)，揭示WNT2在结直肠癌干细胞中特异性高表达，提示其作为潜在治疗靶点。
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**备注**：以上内容为示例，实际文献需通过PubMed、Google Scholar等平台以关键词“WNT2 antibody” + 研究领域(如癌症、干细胞)检索真实文献。建议优先选择近5年高影响力期刊(如Nature, Cancer Research)的研究。
The WNT2 antibody is a crucial tool for studying the WNT2 protein, a member of the Wnt family of secreted signaling glycoproteins. Wnt proteins play pivotal roles in embryonic development, tissue homeostasis, and cell proliferation/differentiation via evolutionarily conserved pathways, primarily the canonical Wnt/β-catenin signaling. WNT2. encoded by the WNT2 gene, binds to Frizzled receptors and co-receptors (e.g., LRP5/6), activating downstream targets like β-catenin to regulate gene expression. Dysregulation of WNT2 is implicated in cancers (e.g., lung, colorectal), fibrosis, and developmental disorders, making it a research focus in oncology and regenerative medicine.
WNT2 antibodies are designed to detect and quantify WNT2 expression in various experimental models. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA to study WNT2's localization, expression levels, and interactions. Due to WNT2's post-translational lipid modifications (e.g., palmitoylation), antibody specificity is critical, requiring validation in knockout controls. Some antibodies block WNT2 function, aiding mechanistic studies. Commercial WNT2 antibodies vary in clonality (monoclonal/polyclonal), species reactivity (human, mouse, rat), and applications, necessitating careful selection based on experimental needs. Their utility extends to exploring WNT2's role in disease pathways and therapeutic targeting.
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