| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | AID; ARP2; CDA2; HIGM2; HEL-S-284 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human AICDA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AICDA抗体的示例参考文献(注：文献为虚构示例，仅供格式参考)：
1. **文献名称**：*AID-Specific Antibody Development and Its Application in Detecting B-Cell Hypermutation*
**作者**：Johnson R. et al.
**摘要**：开发了一种高特异性AICDA单克隆抗体，用于检测生发中心B细胞中的AICDA表达，并验证其在体细胞超突变研究中的应用。
2. **文献名称**：*AICDA Overexpression in Diffuse Large B-Cell Lymphoma: Prognostic Implications*
**作者**：Chen L. et al.
**摘要**：通过免疫组化(使用AICDA抗体)分析DLBCL患者肿瘤样本，发现AICDA高表达与基因组不稳定性和不良预后相关。
3. **文献名称**：*Role of AICDA in Autoantibody Production in Systemic Lupus Erythematosus*
**作者**：Martinez S. et al.
**摘要**：利用AICDA抗体检测SLE患者外周B细胞，发现AICDA异常激活导致自身抗体生成，提示其作为治疗靶点的潜力。
4. **文献名称**：*A Novel Flow Cytometry Method for AID Detection Using Phosphate-Based Antibodies*
**作者**：Kim H. et al.
**摘要**：开发了一种基于磷酸化特异性AICDA抗体的流式细胞术方法，用于实时监测B细胞活化过程中的AICDA活性。
(实际文献请通过PubMed、Web of Science等数据库以关键词“AICDA antibody”或“AID antibody”检索。)
The AICDA antibody targets the Activation-Induced Cytidine Deaminase (AICDA/AID), a key enzyme in adaptive immunity. Expressed primarily in activated B cells, AICDA drives antibody diversification through somatic hypermutation (SHM) and class switch recombination (CSR) by deaminating cytidine to uracil in immunoglobulin genes. This process introduces mutations or DNA breaks, enabling high-affinity antibody production and isotype switching. While essential for immune defense, dysregulated AICDA activity is linked to genomic instability, autoimmune disorders, and B-cell malignancies like lymphoma.
AICDA antibodies are vital research tools for detecting AICDA expression in immune cells, tumor tissues, or experimental models. They help elucidate its role in antibody maturation, cancer biology, and genome editing mechanisms. In diagnostics, these antibodies assist in identifying AICDA overexpression in lymphomas or autoimmune conditions. Therapeutic applications are also being explored, including inhibitors to curb AICDA's mutagenic potential in cancers. However, its transient expression and tight regulation pose challenges for consistent detection, requiring validated antibodies with high specificity. Overall, AICDA antibodies bridge fundamental research and clinical insights into immune regulation and disease pathogenesis. (299 words)
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