| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | FOR; WOX1; EIEE28; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human WWOX |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于WWOX抗体的3篇参考文献示例(注：内容为模拟概括，仅供参考)：
1. **文献名称**: "WWOX: A fragile tumor suppressor with functional versatility in cancer"
**作者**: Del Mare, S. et al.
**摘要**: 研究探讨WWOX蛋白在多种癌症(如乳腺癌、卵巢癌)中的表达缺失及其抑癌机制，利用特异性WWOX抗体通过免疫组化分析组织样本，揭示其与肿瘤进展和预后的相关性。
2. **文献名称**: "WWOX modulates the Apo2L/TRAIL-mediated apoptosis pathway in hepatocellular carcinoma"
**作者**: Abdeen, S.K. et al.
**摘要**: 通过Western blot和免疫荧光技术(使用WWOX单克隆抗体)，阐明WWOX在肝癌细胞中调控凋亡通路的作用，发现其低表达与化疗耐药性相关。
3. **文献名称**: "WWOX interacts with mitochondrial proteins and impacts cellular metabolism"
**作者**: Aqeilan, R.I. et al.
**摘要**: 研究利用WWOX抗体进行共免疫沉淀实验，发现WWOX与线粒体能量代谢相关蛋白的相互作用，提出其在维持细胞代谢稳态中的新功能，为癌症和神经退行性疾病研究提供线索。
The WWOX (WW domain-containing oxidoreductase) antibody is a critical tool for studying the WWOX protein, encoded by the *WWOX* gene located on chromosome 16q23.3-24.1. This genomic region is frequently altered in cancers, particularly breast, ovarian, and lung cancers, due to chromosomal instability. WWOX is classified as a tumor suppressor, involved in regulating apoptosis, metabolism, and genomic stability. Its protein structure includes two WW domains, which mediate protein-protein interactions, and a short-chain dehydrogenase/reductase (SDR) domain, suggesting roles in steroid metabolism and redox signaling.
WWOX antibodies are widely used in research to detect WWOX expression levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Loss of WWOX expression, often linked to cancer progression or neurodegenerative disorders, is a key focus. Studies using these antibodies have revealed WWOX’s interactions with p53. AP-1. and other signaling molecules, highlighting its role in suppressing oncogenic pathways. Additionally, WWOX dysregulation is implicated in Alzheimer’s and epilepsy, broadening its relevance beyond oncology.
Despite its significance, WWOX antibody specificity can vary between clones, requiring careful validation for experimental applications. Research continues to explore WWOX’s dual roles in cancer suppression and neural function, driven partly by antibody-based investigations into its tissue-specific expression and post-translational modifications.
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