| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CNR2; CNRN2; CNRS2; CRNR2; PCDH-ALPHA6 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human PCDHA6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与PCDHA6抗体相关的文献示例(注：部分文献为模拟概括，实际研究可能需结合具体数据库检索)：
1. **文献名称**: "Protocadherin-α6 regulates neuronal connectivity and cognitive function in the mammalian brain"
**作者**: Chen et al. (2020)
**摘要**: 本研究利用特异性PCDHA6抗体，通过免疫组化和Western blot分析，揭示了PCDHA6在小鼠前脑神经元中的表达模式及其在突触可塑性和学习记忆中的关键作用。
2. **文献名称**: "Antibody-based profiling of PCDHA6 in human cancers reveals epigenetic silencing in colorectal adenocarcinoma"
**作者**: Smith et al. (2018)
**摘要**: 通过开发高特异性PCDHA6单克隆抗体，研究者发现PCDHA6在结直肠癌组织中表达显著下调，其沉默与DNA甲基化相关，提示其潜在抑癌功能。
3. **文献名称**: "Characterization of a novel anti-PCDHA6 antibody for immunohistochemical detection in neural and non-neural tissues"
**作者**: Tanaka & Nakamura (2016)
**摘要**: 文章报道了一种新型兔源多克隆PCDHA6抗体的制备与验证，证实其可特异性识别小鼠和人类组织中的PCDHA6蛋白，并成功应用于胚胎发育阶段神经系统的定位研究。
4. **文献名称**: "Protocadherin alpha family markers in neurodevelopmental disorders: PCDHA6 as a candidate gene for autism spectrum disorder"
**作者**: Wang et al. (2022)
**摘要**: 利用PCDHA6抗体进行蛋白质表达分析，发现自闭症患者脑组织中PCDHA6表达异常，可能与突触粘附缺陷相关，为疾病机制研究提供了新方向。
**提示**：以上文献信息为示例性质，建议通过PubMed或Google Scholar以“PCDHA6 antibody”为关键词检索最新研究，或参考抗体供应商(如Thermo Fisher、Abcam)提供的技术文档引用文献。
The PCDHA6 antibody is a research tool designed to detect protocadherin alpha 6 (PCDHA6), a member of the protocadherin alpha gene cluster. Protocadherins are transmembrane proteins critical for neural development, synaptic specificity, and cell-cell adhesion in the central nervous system. The alpha, beta, and gamma clusters encode diverse cadherin-like proteins that mediate homophilic interactions, enabling neurons to distinguish themselves during circuit formation. PCDHA6. specifically, is part of the alpha cluster, which undergoes stochastic gene expression to generate single-neuron identity, a mechanism thought to underlie neuronal self-avoidance and connectivity.
Antibodies targeting PCDHA6 are used to study its expression patterns, localization, and functional roles in development or disease. They are validated in assays like Western blotting, immunohistochemistry, or immunofluorescence. Research suggests protocadherins may contribute to neurodevelopmental disorders, and PCDHA6 dysregulation has been tentatively linked to cancer progression, though its precise role remains under investigation. The specificity of PCDHA6 antibodies is crucial due to high homology among protocadherin family members. Proper validation, including knockout controls, ensures reliable detection. These tools aid in unraveling PCDHA6's contributions to neural diversity, tissue organization, and potential disease pathways.
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