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Rabbit Polyclonal HOXA3 Antibody

  • 中文名: HOXA3抗体
  • 别    名: HOX1; HOX1E
货号: IPDX05789
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesHOX1; HOX1E
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human HOXA3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于HOXA3抗体的参考文献示例(注:以下为假设性示例,建议通过PubMed或Google Scholar检索真实文献):

1. **文献名称**:*HOXA3 Expression in Embryonic Development*

**作者**:Smith A, et al.

**摘要**:本研究利用HOXA3特异性抗体,通过免疫组化技术揭示了HOXA3蛋白在小鼠胚胎咽弓区域的时空表达模式,证实其在咽部器官发育中的关键作用。

2. **文献名称**:*HOXA3 Dysregulation in Breast Cancer Metastasis*

**作者**:Lee B, et al.

**摘要**:通过Western blot和免疫荧光技术,作者发现HOXA3在乳腺癌细胞中异常高表达,并证明其通过调控EMT(上皮-间质转化)促进肿瘤侵袭转移。

3. **文献名称**:*HOXA3 Antibody Validation for ChIP-seq Analysis*

**作者**:Garcia R, et al.

**摘要**:本文系统验证了HOXA3抗体的特异性,成功应用于染色质免疫沉淀(ChIP),揭示了HOXA3在成肌细胞分化中靶向调控的基因网络。

4. **文献名称**:*HOXA3 in Neural Crest Cell Migration*

**作者**:Chen L, et al.

**摘要**:研究利用HOXA3抗体阻断实验,证明其在神经嵴细胞迁移中的功能,为颅面部发育异常提供了分子机制解释。

**建议**:实际文献可通过关键词“HOXA3 antibody”在PubMed(https://pubmed.ncbi.nlm.nih.gov)或Google Scholar中检索,筛选应用该抗体的功能研究或抗体验证相关论文。

背景信息

The HOXA3 antibody is a crucial tool in developmental biology and oncology research, targeting the Homeobox protein Hox-A3 encoded by the HOXA3 gene. HOX genes, highly conserved across species, regulate embryonic patterning, cell differentiation, and organogenesis by controlling spatial-temporal gene expression. HOXA3. part of the HOXA cluster on chromosome 7. plays a pivotal role in anterior-posterior axis formation, particularly in pharyngeal arch development, neural crest cell migration, and thymus/thyroid organogenesis. Dysregulation of HOXA3 has been implicated in cancers (e.g., leukemia, breast cancer) and congenital disorders. The HOXA3 antibody, typically produced in rabbits or mice as monoclonal or polyclonal variants, enables detection of HOXA3 protein expression and localization via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Researchers utilize it to investigate HOXA3's roles in developmental abnormalities, cancer progression, and epigenetic regulation. Validation parameters include specificity checks using knockout controls and cross-reactivity assessments. Commercial antibodies often cite applications in formalin-fixed paraffin-embedded (FFPE) tissues and frozen sections, with molecular weight detection around ~37 kDa. Its utility spans basic developmental studies and clinical research exploring HOXA3 as a potential diagnostic or therapeutic target.

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