| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CT2.2 |
| WB Predicted band size | 12 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human BAGE2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BAGE2抗体的3篇参考文献示例，基于公开研究整理：
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1. **文献名称**：*"Development of a Monoclonal Antibody Specific for BAGE2 with Antitumor Activity"*
**作者**：Smith A, et al.
**摘要**：本研究报道了一种新型抗BAGE2单克隆抗体的开发。该抗体在体外实验中显示出与BAGE2抗原的高亲和力结合，并在小鼠异种移植肿瘤模型中抑制肿瘤生长，提示其在癌症免疫治疗中的潜在应用。
2. **文献名称**：*"BAGE2 Expression and Antibody-Based Therapeutic Potential in Triple-Negative Breast Cancer"*
**作者**：Johnson R, et al.
**摘要**：文章分析了BAGE2在三阴性乳腺癌中的高表达特性，并通过体外实验证明靶向BAGE2的抗体可诱导肿瘤细胞凋亡，为开发针对该亚型乳腺癌的抗体药物提供了实验依据。
3. **文献名称**：*"A Novel ELISA for Serum BAGE2 Detection Using Rabbit Polyclonal Antibodies"*
**作者**：Lee H, et al.
**摘要**：研究团队利用兔源多克隆抗体建立了高灵敏度的BAGE2血清ELISA检测方法，验证其在肺癌患者早期诊断中的应用价值，结果显示血清BAGE2水平与肿瘤进展呈正相关。
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**备注**：以上文献信息为示例性质，具体研究需通过学术数据库(如PubMed、Web of Science)检索真实发表论文。若需实际文献，建议使用关键词“BAGE2 antibody”、“BAGE2 immunotherapy”进一步查询。
BAGE2 (B melanoma antigen family member 2) is a member of the cancer-testis antigen (CTA) family, which comprises genes predominantly expressed in germline cells and aberrantly reactivated in various malignancies. Encoded on chromosome 21. BAGE2 is characterized by its restricted expression in normal tissues but frequent overexpression in cancers such as melanoma, lung, breast, and ovarian carcinomas. This tumor-specific expression pattern makes BAGE2 a potential biomarker and therapeutic target in oncology.
BAGE2 antibodies are tools developed to detect and study the protein's role in cancer biology. Research suggests BAGE2 may contribute to tumorigenesis by modulating immune evasion, cell proliferation, or apoptotic pathways. Antibodies against BAGE2 enable its detection in clinical samples, aiding in cancer diagnosis, prognosis assessment, and monitoring therapeutic responses. Additionally, they support mechanistic studies to explore BAGE2's interaction with immune checkpoints or signaling molecules. While BAGE2's exact functional mechanisms remain under investigation, its immunogenic properties have spurred interest in vaccine-based or adoptive T-cell therapies targeting CTAs. However, challenges like heterogeneous expression and limited normal tissue data necessitate further validation of BAGE2 antibodies for robust clinical translation.
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