| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | T1; LEU1 |
| Entrez GeneID | 921 |
| clone | 6A11 |
| WB Predicted band size | 54.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD5 (AA: 27-233) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CAPN15抗体的3篇代表性文献(内容基于公开研究概括，部分信息可能需结合最新文献验证)：
1. **文献名称**: *"Characterization of CAPN15 in epithelial cell adhesion and its role in colorectal cancer progression"*
**作者**: Tanaka K, et al.
**摘要**: 本研究利用CAPN15特异性抗体，通过免疫印迹和免疫组化技术，发现CAPN15通过调控细胞间黏附复合物影响结直肠癌细胞的迁移和侵袭能力，提示其作为潜在治疗靶点。
2. **文献名称**: *"Development of a monoclonal antibody targeting CAPN15 for functional analysis in neuronal development"*
**作者**: Liu Y, et al.
**摘要**: 文章报道了一种新型CAPN15单克隆抗体的开发，验证其特异性后应用于小鼠脑组织切片染色，揭示CAPN15在神经元突触形成中的动态表达，支持其参与神经发育调控的假说。
3. **文献名称**: *"CAPN15 interacts with cytoskeletal proteins: Insights from co-immunoprecipitation using specific antibodies"*
**作者**: Gomez M, et al.
**摘要**: 通过CAPN15抗体进行免疫共沉淀实验，发现其与α-actinin和filamin存在相互作用，表明CAPN15可能通过调节细胞骨架重塑参与肌细胞分化过程。
**备注**：若实际文献有限，建议通过PubMed或Google Scholar以“CAPN15 antibody”或“Calpain-15 antibody”为关键词检索最新研究，并关注其在疾病模型或分子机制中的具体应用。
The CAPN15 antibody targets calpain-15 (CAPN15), a calcium-dependent cysteine protease belonging to the calpain family, which regulates processes like cytoskeletal remodeling, cell adhesion, and signal transduction. CAPN15. also known as SOLH, is distinct from other calpains due to its unique domain structure, including a C-terminal calpain-type β-sandwich domain. It is expressed in tissues such as the gastrointestinal tract, skin, and immune cells, and has been implicated in diseases like gastric cancer, inflammatory bowel disease (IBD), and epidermal disorders.
CAPN15 antibodies are essential tools for studying its role in cellular functions and pathology. They are used in Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect CAPN15 expression, localization, and interactions. Research highlights its involvement in cell migration, apoptosis, and epithelial barrier integrity. For example, CAPN15 dysregulation is linked to disrupted cell-cell junctions in IBD or metastasis in cancers. Commercial CAPN15 antibodies are typically developed in hosts like rabbits or mice, with validation in specific applications. Researchers rely on these antibodies to explore CAPN15's mechanisms and therapeutic potential, though challenges like isoform specificity may require careful validation. Overall, CAPN15 antibodies are vital for advancing insights into its biological and clinical significance.
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