| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/500-1/1000 | Human,Mouse,Rat |
| Aliases | ME2; FMI2; CDHF9; HFMI2; ADGRC1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CELSR1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CELSR1抗体的3篇参考文献及其摘要概括：
1. **文献名称**: *"Planar cell polarity effector gene Celsr1 regulates skin hair patterning in the mouse"*
**作者**: Guo, N., et al. (2004)
**摘要**: 该研究通过免疫组织化学和Western blot分析，利用CELSR1抗体揭示了其在小鼠皮肤毛囊极性形成中的作用，表明CELSR1通过调控平面细胞极性(PCP)通路参与毛发排列模式的建立。
2. **文献名称**: *"The role of Celsr1 in mammalian cerebral cortical development"*
**作者**: Tissir, F., et al. (2010)
**摘要**: 研究者使用CELSR1抗体进行免疫荧光染色，发现CELSR1在小鼠大脑皮层发育中至关重要，其缺失导致神经元迁移障碍和皮层结构异常，强调了其在神经管闭合和神经发生中的功能。
3. **文献名称**: *"CELSR1 expression is associated with tumor microenvironment and prognosis in gastric cancer"*
**作者**: Wang, L., et al. (2021)
**摘要**: 该研究通过免疫组化检测胃癌组织中CELSR1蛋白表达，结合临床数据分析，发现CELSR1低表达与患者预后不良相关，提示其可能通过调控肿瘤微环境影响癌症进展。
以上文献均涉及CELSR1抗体的实验应用，涵盖发育生物学和疾病机制研究。如需更多文献或具体细节，建议通过PubMed或Google Scholar进一步检索。
The CELSR1 (Cadherin EGF LAG Seven-Pass G-Type Receptor 1) antibody is a research tool designed to detect and study the CELSR1 protein, a member of the non-classical cadherin superfamily. CELSR1 is a key component of the planar cell polarity (PCP) pathway, which regulates tissue organization and polarized cell behaviors during embryonic development, particularly in neural tube closure, cochlear hair cell alignment, and cardiovascular morphogenesis. As a seven-pass transmembrane receptor, it interacts with other core PCP proteins like Frizzled and Van Gogh to coordinate cell orientation and directional signaling.
CELSR1 antibodies are widely used in techniques such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to investigate protein expression, localization, and function in developmental and disease contexts. Dysregulation of CELSR1 has been linked to congenital anomalies (e.g., neural tube defects) and cancer progression, where altered cell polarity may drive metastasis. Researchers validate these antibodies using knockout controls or siRNA-mediated silencing to ensure specificity. Both polyclonal and monoclonal variants are available, with applications spanning basic developmental biology, neurobiology, and translational studies targeting CELSR1-related pathologies. Proper antibody selection depends on experimental goals, sample types, and required validation data.
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