| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | P42; KKIALRE |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CDKL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CDKL1抗体的3篇示例参考文献(注：文献信息为模拟示例，实际引用需查询真实数据库)：
1. **文献名称**：*CDKL1 Expression in Colorectal Cancer: A Novel Prognostic Biomarker*
**作者**：Wang et al. (2019)
**摘要**：研究通过免疫组化(IHC)和Western blot分析CDKL1蛋白在结直肠癌组织中的表达，发现CDKL1高表达与患者生存率降低相关，提示其可能作为预后标志物。
2. **文献名称**：*Development of a Monoclonal Antibody Specific to CDKL1 for Cell Cycle Analysis*
**作者**：Tanaka et al. (2016)
**摘要**：报道了一种高特异性CDKL1单克隆抗体的开发，验证了其在流式细胞术和免疫荧光中的有效性，揭示CDKL1在G2/M期细胞中的定位变化。
3. **文献名称**：*CDKL1 Regulates Neuronal Morphogenesis via MAPK Signaling Pathways*
**作者**：Chen et al. (2021)
**摘要**：利用CDKL1抗体进行免疫沉淀和免疫印迹实验，发现CDKL1通过调控MAPK通路影响神经元突触发育，为神经系统疾病机制提供新见解。
**建议**：实际研究中请通过PubMed或Google Scholar检索真实文献，关键词“CDKL1 antibody”、“CDKL1 function”或结合具体研究领域(如癌症、神经科学)。
The CDKL1 antibody is a crucial tool in studying the function of Cyclin-Dependent Kinase-Like 1 (CDKL1), a serine/threonine kinase belonging to the CDK family. CDKL1 shares structural homology with other CDK-related proteins but exhibits distinct regulatory roles, primarily implicated in cell cycle progression, signal transduction, and cellular differentiation. Although less characterized than its paralog CDKL5 (linked to neurodevelopmental disorders), CDKL1 is thought to influence cell proliferation and tissue development through phosphorylation-mediated pathways. Its expression has been observed in various tissues, including the brain, testis, and certain cancers, suggesting potential roles in oncogenesis or tissue homeostasis.
CDKL1 antibodies are widely used in research to detect and quantify CDKL1 protein levels via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies aid in elucidating CDKL1's subcellular localization, interaction partners, and expression patterns under physiological or pathological conditions. For instance, studies have explored CDKL1's overexpression in cancers such as hepatocellular carcinoma, where it may promote tumor growth. Validated antibodies often undergo specificity checks using knockout controls or siRNA-mediated knockdown to ensure accurate detection.
Despite its emerging significance, CDKL1's precise mechanisms remain under investigation. The antibody thus serves as a vital reagent for uncovering its biological and clinical relevance, particularly in cancer research and developmental biology.
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