| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CBLN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CBLN1抗体的3篇参考文献示例，涵盖其功能及应用研究：
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1. **文献名称**：*Cerebellin 1 is essential for synaptic integrity and plasticity in the cerebellum*
**作者**：Hirai H., Pang Z., Bao H., Miyazaki T.
**摘要**：通过CBLN1抗体进行免疫组织化学分析，揭示了CBLN1在小脑颗粒细胞与浦肯野细胞突触中的关键作用，证明其缺失导致突触结构破坏及运动学习缺陷。
2. **文献名称**：*CBLN1 regulates synapse formation by bridging neurexin and glutamate receptor δ2*
**作者**：Uemura T., Lee S.J., Yasumura M. 等
**摘要**：利用特异性抗体证实CBLN1作为突触粘附分子，通过结合突触前膜Neurexin和突触后膜GluD2.介导小脑兴奋性突触的组装与功能。
3. **文献名称**：*Autoantibodies against CBLN1 in paraneoplastic cerebellar degeneration*
**作者**：Joo J.Y., Lee K.H., Kim Y.J.
**摘要**：研究报道CBLN1抗体在副肿瘤性小脑变性患者中的异常表达，提示其可能通过靶向CBLN1破坏突触稳态，导致共济失调症状。
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**注**：以上文献为示例，实际引用时请通过PubMed或Google Scholar核对最新研究及准确来源。
CBLN1 (Cerebellin-1) is a secreted glycoprotein belonging to the cerebellin family, predominantly expressed in the cerebellum and crucial for synaptic organization in the central nervous system. It plays a key role in the formation and maintenance of excitatory synapses by bridging presynaptic neurexins to postsynaptic glutamate receptor delta subunits (GluD1/2). This interaction is essential for synaptic plasticity, neuronal connectivity, and circuit refinement, particularly during development. Dysregulation of CBLN1 has been linked to neurodevelopmental disorders such as autism spectrum disorder (ASD), schizophrenia, and spinocerebellar ataxia, highlighting its importance in brain function and disease.
Antibodies targeting CBLN1 are vital tools for investigating its expression, localization, and molecular interactions. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding studies on synaptic pathology. Validated CBLN1 antibodies help dissect its role in synapse formation, behavioral phenotypes, and disease mechanisms, offering insights into therapeutic targets. Researchers prioritize antibodies with high specificity and cross-reactivity validation across species (e.g., human, mouse, rat) to ensure experimental reliability. As CBLN1 gains attention in neuroscience, its antibodies remain critical for advancing understanding of synaptic biology and neuropsychiatric disorders.
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