| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ALC1; CHDL |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CHD1L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于CHD1L抗体的参考文献概览：
1. **文献名称**：CHD1L is a novel oncogene promoting cell proliferation via modulating the G1/S phase checkpoint in hepatocellular carcinoma
**作者**：Ma NF et al.
**摘要**：该研究利用CHD1L抗体进行免疫组化(IHC)和Western blot分析，发现CHD1L在肝癌组织中过表达，并通过调控细胞周期蛋白(如Cyclin E和CDK2)促进肿瘤细胞增殖。抗体的特异性验证为后续功能研究提供了支持。
2. **文献名称**：Amplification of CHD1L in hepatocellular carcinoma and its role as a potential therapeutic target
**作者**：Chen L et al.
**摘要**：通过CHD1L抗体检测肝癌样本中CHD1L的基因扩增与蛋白表达水平，发现其过表达与患者不良预后相关。研究进一步使用siRNA和抗体阻断实验，证实CHD1L可作为肝癌治疗的潜在靶点。
3. **文献名称**：The role of CHD1L in DNA damage repair and chemoresistance in ovarian cancer
**作者**：Wang Y et al.
**摘要**：该研究采用CHD1L抗体进行免疫荧光染色，发现CHD1L通过同源重组修复(HRR)通路参与卵巢癌的DNA损伤修复，其高表达导致铂类化疗耐药，为临床耐药机制提供了新见解。
注：上述文献为示例，实际引用时需以具体数据库(如PubMed)检索结果为准。若需准确文献，建议通过关键词“CHD1L antibody”或“CHD1L immunohistochemistry”在学术平台查询近年发表的研究。
The CHD1L (Chromodomain Helicase DNA Binding Protein 1-Like) antibody is a key tool for studying the CHD1L protein, a member of the SNF2-like superfamily of ATP-dependent chromatin-remodeling proteins. CHD1L, also known as ALC1 (Amplified in Liver Cancer 1), is encoded by a gene located on chromosome 1q21. a region frequently amplified in various cancers, particularly hepatocellular carcinoma (HCC). This protein plays critical roles in DNA damage repair, replication, and transcriptional regulation by altering chromatin structure through ATP hydrolysis. Its involvement in maintaining genomic stability and promoting tumorigenesis has made it a focus in cancer research, especially as a potential biomarker for cancer prognosis and therapeutic targeting.
CHD1L antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect CHD1L expression levels in tissues or cell lines. Studies have linked CHD1L overexpression to aggressive cancer phenotypes, metastasis, and poor patient outcomes, highlighting its oncogenic potential. Additionally, CHD1L is implicated in stem cell pluripotency and developmental processes, expanding its relevance beyond oncology. Researchers also investigate its interaction with PARP1 (Poly-ADP Ribose Polymerase 1) during DNA repair, shedding light on mechanisms of chemoresistance. The development of specific, high-affinity CHD1L antibodies remains essential for elucidating its biological functions and clinical applications.
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