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Rabbit Polyclonal NTNG2 Antibody

  • 中文名: NTNG2抗体
  • 别    名: Lmnt2; NTNG1; LHLL9381; bA479K20.1
货号: IPDX06227
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesLmnt2; NTNG1; LHLL9381; bA479K20.1
WB Predicted band size60 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human NTNG2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于NTNG2抗体的3篇参考文献及其摘要概括:

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1. **文献名称**:*Netrin-G2 regulates cortical synapse density and behavior through the laminar-specific receptor LRRTM4*

**作者**:Soto F et al.

**摘要**:研究利用NTNG2抗体进行免疫印迹和免疫荧光染色,揭示Netrin-G2通过与层特异性受体LRRTM4互作调控小鼠皮质突触密度,并影响社交行为。抗体验证了NTNG2在皮质不同层中的差异表达。

2. **文献名称**:*NTNG2 mutations alter postsynaptic organization in human neurons*

**作者**:Mount RA et al.

**摘要**:通过CRISPR技术构建NTNG2突变神经元模型,结合NTNG2抗体进行免疫细胞化学分析,发现突变导致突触后蛋白(如PSD95)定位异常,提示其在神经发育障碍中的潜在作用。

3. **文献名称**:*Differential expression of Netrin-G2 in gliomas correlates with tumor grade and survival*

**作者**:Chen L et al.

**摘要**:采用NTNG2抗体对胶质瘤组织进行免疫组化分析,发现高级别肿瘤中NTNG2表达显著下调,且低表达患者预后较差,提示其作为胶质瘤分级标志物的可能性。

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以上文献展示了NTNG2抗体在神经发育、疾病机制及肿瘤研究中的应用,涵盖分子机制探索和临床相关性分析。如需具体文献来源,建议通过PubMed或Google Scholar按标题检索。

背景信息

The NTNG2 antibody targets Netrin-G2 (NTNG2), a member of the netrin family of axon guidance proteins. Unlike classical netrins, NTNG1 and NTNG2 are glycosylphosphatidylinositol (GPI)-anchored cell membrane proteins predominantly expressed in the central nervous system. NTNG2 is enriched in thalamocortical and corticothalamic projections, playing a critical role in establishing neural connectivity during development. It interacts with its receptor, LRRC4C (also known as NGL-1), to regulate synapse formation, maintenance, and plasticity. Dysregulation of NTNG2 signaling has been implicated in neurodevelopmental disorders, including schizophrenia and autism spectrum disorders (ASD). Antibodies against NTNG2 are essential tools for studying its expression patterns, subcellular localization, and function in both healthy and diseased states. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize NTNG2 distribution in brain tissues or cultured neurons. Recent studies also utilize NTNG2 antibodies to explore its potential as a biomarker or therapeutic target in neurological conditions. Researchers prioritize antibodies with high specificity and validated cross-reactivity across species (e.g., human, mouse) to ensure experimental reproducibility.

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