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Rabbit Polyclonal CNOT4 Antibody

  • 中文名: CNOT4抗体
  • 别    名: NOT4; NOT4H; CLONE243
货号: IPDX06213
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

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参考文献

以下是3篇与CNOT4抗体相关的文献摘要(文献标题及内容为虚构示例,仅供格式参考):

1. **"CNOT4 mediates ubiquitination and degradation of nuclear receptors"**

*Author: Li Y, et al.*

摘要:研究利用CNOT4特异性抗体进行免疫共沉淀实验,发现CNOT4通过E3泛素连接酶活性调控核受体(如ERα)的泛素化及降解,影响乳腺癌细胞增殖。

2. **"Structural analysis of the CCR4-NOT complex subunit CNOT4"**

*Author: Takahashi S, et al.*

摘要:通过CNOT4抗体进行Western blot和免疫荧光定位,揭示CNOT4在细胞核内的分布及其与CCR4-NOT复合物其他亚基的相互作用结构域。

3. **"CNOT4 deficiency impairs mRNA deadenylation and viral defense"**

*Author: Müller R, et al.*

摘要:研究利用CNOT4敲除小鼠模型及特异性抗体,证明CNOT4缺失导致mRNA脱腺苷化功能受损,降低宿主细胞对RNA病毒的免疫应答。

注:以上内容为模拟生成,实际文献需通过PubMed或Google Scholar检索关键词(如"CNOT4 antibody" + "function")。

背景信息

The CNOT4 antibody is a tool used to detect CNOT4. a subunit of the CCR4-NOT complex, which plays critical roles in post-transcriptional gene regulation. CNOT4. a conserved E3 ubiquitin ligase, is involved in mRNA deadenylation, decay, and translational repression, contributing to cellular processes like stress responses, cell cycle regulation, and immune function. The CCR4-NOT complex acts as a global regulator of gene expression, interacting with RNA-binding proteins and miRNAs to fine-tune mRNA stability and translation. CNOT4 specifically facilitates ubiquitination of target proteins, influencing their stability or activity. Antibodies against CNOT4 enable researchers to study its expression, localization, and interactions in various biological contexts, including cancer, neurodevelopment, and viral infections. These antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence, aiding in elucidating CNOT4's role in maintaining cellular homeostasis and its dysregulation in diseases. Recent studies also explore CNOT4's potential as a therapeutic target, highlighting its importance in gene regulatory networks.

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