| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AMY; CLAC; CLACP; CFEOM5; CLAC-P |
| WB Predicted band size | 65 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human COL25A1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇与COL25A1抗体相关的文献概览(均为模拟示例，实际文献需通过数据库验证)：
1. **文献名称**: *Collagen XXV interacts with amyloid-β to promote plaque formation in Alzheimer's disease*
**作者**: Yamaguchi H. et al.
**摘要**: 研究发现COL25A1在阿尔茨海默病(AD)患者脑组织中高表达，其抗体标记显示胶原XXV与β-淀粉样蛋白(Aβ)共定位，提示其在淀粉样斑块形成中的潜在作用。
2. **文献名称**: *COL25A1 as a cerebrospinal fluid biomarker for neurodegenerative diseases*
**作者**: Söderberg M. et al.
**摘要**: 通过COL25A1抗体检测脑脊液中的胶原XXV水平，发现其在AD和路易体痴呆患者中显著升高，表明其可能作为神经退行性疾病的生物标志物。
3. **文献名称**: *Characterization of collagen XXV expression in mouse models of muscular dystrophy*
**作者**: Määttä A. et al.
**摘要**: 利用COL25A1抗体分析显示，胶原XXV在肌肉营养不良模型小鼠的神经肌肉接头处特异性富集，提示其参与突触外基质的稳定。
4. **文献名称**: *Immunolocalization of collagen XXV in developing and adult human tissues*
**作者**: Härtig W. et al.
**摘要**: 通过免疫组化结合COL25A1抗体，揭示胶原XXV在胚胎发育期神经管及成人中枢神经系统中的动态表达模式，强调其在组织分化中的潜在功能。
注：以上为模拟生成内容，实际文献需通过PubMed、Web of Science等平台以“COL25A1 antibody”为关键词检索。
The COL25A1 antibody targets collagen type XXV alpha 1 chain (COL25A1), a transmembrane collagen primarily expressed in the central nervous system (CNS). COL25A1 is a component of the extracellular matrix and is notably associated with amyloid-beta (Aβ) plaques in Alzheimer’s disease (AD). It is synthesized by neurons and accumulates at synaptic sites, where it interacts with Aβ peptides, potentially influencing plaque formation and stability. Research suggests COL25A1 may serve as a scaffold for Aβ deposition, contributing to neurotoxicity and disease progression.
COL25A1 antibodies are critical tools for studying its role in neurodegenerative disorders. They enable the detection of COL25A1 in brain tissues via immunohistochemistry, Western blotting, or ELISA, helping to map its distribution in normal and pathological conditions. Studies using these antibodies have revealed elevated COL25A1 levels in AD brains, correlating with Aβ burden and cognitive decline. Additionally, COL25A1 antibodies aid in investigating its interactions with other plaque-associated proteins and its potential as a therapeutic target.
Despite its niche focus, COL25A1 research highlights the interplay between extracellular matrix components and neurodegenerative mechanisms. Antibodies against COL25A1 remain vital for unraveling its biological functions and exploring diagnostic or therapeutic strategies in AD and related dementias.
×
