| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | D6; hD6; CCR9; CCBP2; CCR10; CMKBR9 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ACKR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ACKR2抗体的3篇参考文献，包含文献名称、作者及摘要核心内容：
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1. **文献名称**：*"Atypical Chemokine Receptor 2 (ACKR2) regulates endothelial cell permeability and leukocyte transmigration"*
**作者**：B. A. Zabel et al.
**摘要**：研究利用ACKR2特异性抗体，发现ACKR2通过调控内皮细胞通透性和趋化因子清除，影响白细胞跨内皮迁移，提示其在炎症反应中的关键作用。
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2. **文献名称**：*"ACKR2/D6 suppresses cutaneous inflammation by sequestering pro-inflammatory chemokines in murine models"*
**作者**：C. Weber et al.
**摘要**：通过抗ACKR2抗体的体内阻断实验，证明ACKR2通过结合并降解促炎趋化因子(如CCL2/5)，抑制小鼠皮肤炎症模型中的过度免疫反应。
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3. **文献名称**：*"The role of ACKR2 in tumor-associated lymphatic remodeling and metastasis"*
**作者**：M. T. De Palma et al.
**摘要**：利用ACKR2抗体进行免疫组化分析，发现ACKR2在肿瘤淋巴管内皮细胞高表达，其缺失导致趋化因子累积并促进肿瘤转移，提示其作为癌症治疗潜在靶点。
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这些研究均通过ACKR2抗体揭示了其在炎症调控、免疫微环境和肿瘤转移中的功能机制。如需具体DOI或期刊信息，可进一步补充检索。
ACKR2 (Atypical Chemokine Receptor 2), also known as D6 or CCBP2. is a member of the atypical chemokine receptor family. Unlike classical chemokine receptors, ACKR2 does not activate G protein-mediated signaling pathways. Instead, it functions as a scavenger receptor that binds, internalizes, and degrades inflammatory CC-chemokines (e.g., CCL2. CCL3. CCL5), thereby regulating chemokine bioavailability and immune responses. This decoy activity helps resolve inflammation and maintain tissue homeostasis.
ACKR2 is predominantly expressed on lymphatic endothelial cells and certain immune cells, such as macrophages. Its role in modulating chemokine gradients makes it critical in processes like leukocyte trafficking, inflammatory disease progression, and cancer metastasis. Studies link ACKR2 dysregulation to chronic inflammation, autoimmune disorders, and tumor microenvironment remodeling. For instance, in cancer, ACKR2 may either suppress or promote metastasis depending on context, highlighting its dual roles.
ACKR2 antibodies are essential tools for detecting receptor expression, studying ligand-receptor interactions, and exploring therapeutic targeting. They are widely used in techniques like immunohistochemistry, flow cytometry, and Western blot. Research on ACKR2 continues to uncover its potential as a biomarker or therapeutic target in inflammatory diseases and oncology.
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