Rabbit Polyclonal BHLHA9 Antibody

The BHLHA9 antibody targets the protein product of the *BHLHA9* (Basic Helix-Loop-Helix Family Member A9) gene, a member of the bHLH transcription factor family. BHLHA9 is implicated in developmental processes, particularly limb and tissue morphogenesis, and has gained attention due to its role in certain pathological conditions. Mutations in *BHLHA9* are linked to congenital limb malformations, such as mesoaxial synostotic syndactyly, highlighting its importance in skeletal patterning. Additionally, BHLHA9 has been associated with tumorigenesis, showing altered expression in cancers like rhabdomyosarcoma and soft tissue tumors. The BHLHA9 antibody serves as a critical tool for detecting protein localization and expression levels in research settings, aiding studies on its regulatory mechanisms in development and disease. It is commonly used in techniques such as immunohistochemistry, Western blotting, and immunofluorescence to explore BHLHA9's interaction with signaling pathways (e.g., Wnt/β-catenin) and its potential as a biomarker. Recent studies also investigate its involvement in cell differentiation and proliferation, suggesting therapeutic implications. However, the functional complexity of BHLHA9 warrants further exploration to fully elucidate its molecular roles and clinical relevance.