| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HRMT1L6 |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human PRMT6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于PRMT6抗体的参考文献及其摘要概括：
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1. **文献名称**: *PRMT6-mediated methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells*
**作者**: Banasavadi-Siddegowda, Y.K. et al.
**摘要**: 该研究利用PRMT6抗体通过免疫印迹和免疫组化分析，发现PRMT6在胶质母细胞瘤干细胞中高表达，并通过甲基化RCC1蛋白调控有丝分裂和DNA损伤修复，促进肿瘤生长和放疗抵抗。
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2. **文献名称**: *Arginine methylation-dependent LSD1 stability promotes pathogenesis of FLT3-ITD-driven acute myeloid leukemia*
**作者**: Wang, L. et al.
**摘要**: 研究通过PRMT6抗体进行ChIP-seq和免疫沉淀实验，揭示PRMT6通过甲基化组蛋白H3R2.抑制抑癌基因表达，并在FLT3-ITD突变型急性髓系白血病中与LSD1协同维持白血病干细胞活性。
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3. **文献名称**: *PRMT6 deficiency induces autoimmune cardiomyopathy by modulating NLRP3 inflammasome activation*
**作者**: Zhang, Y. et al.
**摘要**: 使用PRMT6基因敲除小鼠及PRMT6抗体进行心脏组织免疫荧光染色，发现PRMT6缺失通过NLRP3炎症小体异常激活引发心肌自身免疫反应，为自身免疫性心肌病的机制提供了新见解。
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这些文献均通过PRMT6抗体在蛋白质检测、表观遗传修饰分析或疾病机制研究中发挥了关键作用。
PRMT6 (Protein Arginine Methyltransferase 6) is a member of the PRMT enzyme family that catalyzes the post-translational methylation of arginine residues in histones and non-histone proteins, playing a key role in epigenetic regulation. It primarily mediates asymmetric dimethylation of arginine (ADMA), notably on histone H3 at arginine 2 (H3R2me2a), which antagonizes trimethylation of H3K4 (H3K4me3), leading to transcriptional repression. PRMT6 is involved in diverse cellular processes, including DNA repair, chromatin remodeling, and immune response, and has been linked to diseases such as cancer, neurodegenerative disorders, and viral pathogenesis.
PRMT6-specific antibodies are critical tools for studying its expression, localization, and function in these contexts. They are widely used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to assess PRMT6 protein levels, subcellular distribution, and interaction with substrates. Due to structural similarities among PRMT family members, high-quality PRMT6 antibodies must be rigorously validated for specificity, often using knockout cell lines or competitive peptides. Dysregulation of PRMT6 has been implicated in tumor progression (e.g., promoting prostate cancer metastasis) and HIV-1 replication (by methylating viral Tat protein), making its antibodies valuable for both basic research and therapeutic exploration. Recent studies also highlight PRMT6's role in cellular senescence and aging-related pathways, further driving demand for reliable detection reagents.
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