| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CML3; NACED; NAT8-LIKE |
| WB Predicted band size | 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human NAT8L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NAT8L抗体的3篇示例参考文献(注：以下内容为模拟示例，实际文献需通过学术数据库查询)：
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1. **文献名称**: "Development and characterization of a monoclonal antibody specific for human NAT8L protein"
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种高特异性小鼠单克隆抗体，用于检测人脑组织中的NAT8L蛋白表达。通过免疫印迹和免疫组化验证，该抗体能特异性识别NAT8L，并在阿尔茨海默病模型中观察到NAT8L表达下调。
2. **文献名称**: "NAT8L-mediated N-acetylaspartate synthesis in neuronal metabolism"
**作者**: Lee JH, et al.
**摘要**: 文章利用NAT8L抗体探究了该酶在神经元代谢中的作用，发现其通过调控N-乙酰天冬氨酸(NAA)合成影响线粒体功能，抗体在脑切片和原代神经元培养中证实了NAT8L的亚细胞定位。
3. **文献名称**: "Dysregulation of NAT8L in mouse models of Huntington's disease"
**作者**: Chen R, et al.
**摘要**: 研究通过Western blot和免疫荧光(使用兔多克隆NAT8L抗体)发现亨廷顿病小鼠模型的纹状体中NAT8L蛋白水平显著降低，提示其与神经退行性病变的代谢异常相关。
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建议通过PubMed、Google Scholar等平台以关键词“NAT8L antibody”或“NAT8L immunodetection”检索最新文献，获取具体研究数据。
The NAT8L antibody is a crucial tool for studying N-acetyltransferase 8-like (NAT8L), an enzyme encoded by the *NAT8L* gene. NAT8L catalyzes the biosynthesis of N-acetylaspartate (NAA), a highly abundant metabolite in the brain, by transferring an acetyl group from acetyl-CoA to L-aspartate. NAA plays essential roles in neuronal osmoregulation, myelination, and energy metabolism. Dysregulation of NAT8L expression or NAA levels has been implicated in neurological disorders such as Canavan disease, Alzheimer’s disease, and glioblastoma, making NAT8L a potential biomarker or therapeutic target.
The NAT8L antibody is widely used in research to detect and quantify NAT8L protein expression in tissues, particularly in the central nervous system. It enables techniques like Western blotting, immunohistochemistry, and immunofluorescence to localize NAT8L in neurons and oligodendrocytes. Studies using this antibody have revealed NAT8L’s role in maintaining NAA homeostasis and its impact on mitochondrial function. For example, NAT8L knockout models exhibit reduced NAA levels and defects in myelination, underscoring its biological significance.
Commercial NAT8L antibodies are typically validated for specificity and sensitivity across species (e.g., human, mouse, rat). Researchers rely on these antibodies to explore NAT8L’s involvement in neurodevelopment, neurodegeneration, and cancer, offering insights into disease mechanisms and potential interventions.
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