Rabbit Polyclonal ATG2A Antibody

The ATG2A antibody is a research tool used to detect autophagy-related protein 2A (ATG2A), a key player in autophagy—a cellular recycling process critical for maintaining homeostasis. ATG2A, encoded by the *ATG2A* gene, is essential for autophagosome formation, particularly in mediating lipid transfer between membranes to expand the phagophore. It interacts with other autophagy-related proteins like ATG9 and WIPI proteins, facilitating membrane expansion and vesicle closure. Dysregulation of ATG2A is linked to autophagy-related disorders, including neurodegenerative diseases and cancer. Antibodies targeting ATG2A are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to study its expression, localization, and interactions. These antibodies help elucidate ATG2A’s role in autophagy mechanisms, its involvement in cellular stress responses, and potential therapeutic applications. Validation of ATG2A antibodies includes testing specificity via knockout cell lines or siRNA knockdown to ensure accurate detection. Recent studies also explore ATG2A’s non-canonical functions, such as lipid metabolism and organelle crosstalk, broadening its relevance in cell biology research.