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Rabbit Polyclonal COX4I2 Antibody

  • 中文名: COX4I2抗体
  • 别    名: COX4; COX4B; COX4-2; COX4L2; COXIV-2; dJ857M17.2
货号: IPDX06332
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesCOX4; COX4B; COX4-2; COX4L2; COXIV-2; dJ857M17.2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human COX4I2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于COX4I2抗体的3篇参考文献,按作者和内容概括整理:

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1. **标题**: *Tissue-specific regulation of cytochrome c oxidase subunit 4 isoform expression*

**作者**: Hüttemann M et al.

**摘要**: 研究揭示了COX4亚型(包括COX4I2)在不同组织中的表达差异,尤其是在肺和睾丸中的高表达。文章验证了COX4I2抗体的特异性,并证明其在低氧条件下对线粒体功能调控的关键作用。

2. **标题**: *COX4I2 modulates oxygen sensing and mitochondrial respiration in pulmonary arterial smooth muscle cells*

**作者**: Waypa GB et al.

**摘要**: 该文献利用COX4I2抗体探究了其在肺动脉平滑肌细胞中的功能,发现COX4I2通过调节线粒体氧感应通路影响缺氧性肺血管收缩,为肺动脉高压的机制研究提供了依据。

3. **标题**: *Differential expression of mitochondrial COX4 isoforms: Implications for oxygen metabolism and disease*

**作者**: Arnold S et al.

**摘要**: 研究通过COX4I2抗体检测发现,该亚型在肿瘤微环境及缺血性心肌组织中显著上调,提示其可能通过调节能量代谢途径参与疾病进展,为靶向治疗提供潜在方向。

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以上文献均通过COX4I2抗体开展功能研究,涵盖组织特异性表达、疾病机制及氧代谢调控等领域。如需具体DOI或期刊信息,可进一步补充检索关键词(如“COX4I2 antibody validation”)获取技术类文献。

背景信息

The COX4I2 antibody is a valuable tool for studying the cytochrome c oxidase subunit 4 isoform 2 (COX4I2), a tissue-specific component of mitochondrial Complex IV in the electron transport chain. Unlike its ubiquitous isoform COX4I1. COX4I2 is predominantly expressed in oxygen-sensitive or metabolically specialized tissues, such as lung, placenta, and vascular smooth muscle cells. This isoform plays a critical role in adapting cellular respiration to low oxygen conditions, potentially influencing oxygen-sensing pathways and metabolic flexibility. Researchers employ COX4I2 antibodies to investigate its expression patterns, subcellular localization, and regulatory functions under hypoxia or pathological states like pulmonary hypertension and cancer. These antibodies are typically validated for techniques including Western blotting, immunohistochemistry, and immunofluorescence. Studies using COX4I2-specific reagents have revealed its association with metabolic reprogramming in tumors and its potential as a biomarker for hypoxia-related diseases. Ongoing research focuses on its structural differences from COX4I1. tissue-specific regulatory mechanisms, and therapeutic implications in mitochondrial disorders.

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