| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 9 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human COX6C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于COX6C抗体的3篇参考文献示例(文献名称、作者及摘要内容概括)：
1. **文献名称**：*COX6C as a Potential Tumor Suppressor in Colorectal Cancer*
**作者**：Zhang Y, et al.
**摘要**：该研究通过免疫组化和Western blot使用COX6C抗体，发现COX6C在结直肠癌组织中表达显著下调，其低表达与患者不良预后相关，提示COX6C可能通过调控线粒体功能抑制肿瘤进展。
2. **文献名称**：*Mitochondrial Complex IV Dysfunction in Alzheimer's Disease: COX6C Expression Analysis*
**作者**：Smith JL, et al.
**摘要**：研究利用COX6C抗体检测阿尔茨海默病患者脑组织中线粒体复合物IV亚基的表达，发现COX6C蛋白水平降低，可能与神经元能量代谢缺陷及疾病病理相关。
3. **文献名称**：*Validation of a COX6C-Specific Antibody for Mitochondrial Studies*
**作者**：Kim H, et al.
**摘要**：本文验证了一种高特异性COX6C抗体的应用，通过免疫沉淀和质谱分析确认其靶向人源COX6C蛋白的能力，为线粒体呼吸链研究提供了可靠工具。
注：上述文献为示例，实际引用需根据具体研究选择真实发表的论文。建议通过PubMed或Google Scholar检索关键词“COX6C antibody”或“COX6C function”获取最新文献。
The cytochrome c oxidase subunit 6C (COX6C) antibody is a research tool targeting a key component of the mitochondrial electron transport chain. COX6C, a nuclear-encoded subunit of cytochrome c oxidase (Complex IV), plays a critical role in catalyzing the final step of oxidative phosphorylation by transferring electrons to oxygen, coupled with proton pumping across the mitochondrial membrane. This 75-amino-acid protein localizes to the inner mitochondrial membrane and contributes to Complex IV assembly and stability.
COX6C antibodies are widely used to investigate mitochondrial function, cellular energy metabolism, and diseases linked to oxidative phosphorylation defects. They enable detection of COX6C expression levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research has implicated COX6C dysregulation in conditions such as prostate cancer, neurodegenerative disorders (e.g., Parkinson's disease), and mitochondrial myopathies. Some studies suggest COX6C overexpression may serve as a biomarker for certain cancers, while mutations or deficiencies are associated with compromised ATP production and cellular stress.
These antibodies also support studies exploring metabolic adaptations in hypoxia, aging, and exercise physiology. Commercial COX6C antibodies are typically validated for specificity using knockout controls or siRNA-mediated protein suppression. Ongoing research aims to clarify COX6C's regulatory roles beyond electron transport, including potential involvement in apoptosis and ROS signaling pathways.
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