Rabbit Polyclonal ALX4 Antibody

The ALX4 antibody is a research tool designed to detect the ALX4 protein, a member of the Aristaless-related homeobox transcription factor family. ALX4. encoded by the ALX4 gene, plays critical roles in embryonic development, particularly in craniofacial, limb, and genitourinary patterning. It regulates gene expression by binding to DNA through its conserved homeodomain, influencing cellular differentiation and tissue morphogenesis. Dysregulation of ALX4 has been linked to congenital disorders, such as parietal foramina (defects in skull ossification) and developmental abnormalities. In cancer research, ALX4 expression is studied in tumors (e.g., breast, ovarian) as a potential biomarker due to its variable expression in malignancies. The ALX4 antibody is utilized in techniques like immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF) to assess protein localization, expression levels, and molecular interactions. Both monoclonal and polyclonal variants exist, with specificity validated through knockout controls or peptide blocking. Its applications extend to studying ALX4's role in signaling pathways (e.g., Wnt, BMP) and genetic models. Researchers rely on this antibody to explore developmental biology, disease mechanisms, and therapeutic targets, emphasizing its importance in basic and translational studies.