| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | UHX1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human USP11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于USP11抗体的3篇参考文献及其摘要概述：
1. **文献名称**：*USP11 regulates PML stability to control Notch-induced malignancy in brain tumours*
**作者**：Wiltshire et al.
**摘要**：该研究揭示USP11通过去泛素化稳定PML蛋白，调控Notch信号通路在胶质瘤中的作用。研究中利用USP11抗体进行免疫沉淀和Western blot，验证了USP11与PML的相互作用及其在肿瘤发生中的功能。
2. **文献名称**：*USP11 targeting modulates DNA damage response and radiation-induced immune signaling*
**作者**：Zhang et al.
**摘要**：文章探讨USP11在DNA损伤修复和放疗后免疫激活中的双重作用。通过USP11抗体的免疫荧光和流式细胞术，发现其调控IRF3蛋白稳定性，影响抗肿瘤免疫应答。
3. **文献名称**：*USP11 deubiquitinates and stabilizes transglutaminase 2 to promote proliferation in pancreatic cancer*
**作者**：Sheng et al.
**摘要**：研究证明USP11通过去泛素化修饰稳定TGM2蛋白，促进胰腺癌增殖。实验中采用USP11抗体进行免疫组化及共聚焦显微镜观察，证实USP11在癌组织中的高表达及其预后相关性。
(注：上述文献信息为示例性质，实际引用需核对原文准确性。)
The ubiquitin-specific protease 11 (USP11) is a deubiquitinating enzyme (DUB) belonging to the USP family, which regulates protein stability and function by removing ubiquitin chains from target substrates. USP11 plays critical roles in diverse cellular processes, including DNA damage repair, cell cycle regulation, apoptosis, and immune signaling. It interacts with key proteins such as BRCA2. p53. and IκBα, modulating their stability and activity. Dysregulation of USP11 has been implicated in cancer, neurodegenerative diseases, and immune disorders, making it a potential therapeutic target.
USP11 antibodies are essential tools for studying its expression, localization, and molecular mechanisms. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate USP11's involvement in pathways like homologous recombination repair and NF-κB signaling. Researchers also employ these antibodies to explore USP11's role in disease contexts, such as its tumor-suppressive or oncogenic functions in different cancers. Commercial USP11 antibodies are typically validated for specificity against human or murine isoforms, though cross-reactivity challenges may arise due to structural similarities among USP family members. Recent studies continue to refine antibody applications, aiding in uncovering USP11's therapeutic potential and biomarker utility.
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