| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human DMRTA2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DMRTA2抗体的参考文献示例(注：以下内容为模拟示例，实际文献需通过学术数据库查询)：
1. **文献名称**：*Dmrta2 regulates neural progenitor development in the mammalian forebrain*
**作者**：Smith J, et al.
**摘要**：研究利用DMRTA2抗体通过免疫组化和Western blot技术，揭示Dmrta2在小鼠前脑神经祖细胞增殖与分化中的关键作用，并发现其与Foxg1信号通路的相互作用。
2. **文献名称**：*DMRTA2 expression in testicular development and germ cell differentiation*
**作者**：Lee S, et al.
**摘要**：通过DMRTA2抗体的免疫荧光分析，发现DMRTA2在雄性小鼠睾丸发育过程中特异性表达于生殖细胞前体，提示其参与精子形成调控。
3. **文献名称**：*Epigenetic regulation by DMRTA2 in cortical neuron migration*
**作者**：Garcia R, et al.
**摘要**：研究使用DMRTA2抗体进行染色质免疫沉淀(ChIP-seq)，证明DMRTA2通过调控下游靶基因(如Neurod1)的表观遗传修饰影响皮层神经元迁移。
4. **文献名称**：*DMRTA2 as a potential biomarker in neuroblastoma: An immunohistochemical study*
**作者**：Chen H, et al.
**摘要**：基于DMRTA2抗体的免疫组化分析，发现DMRTA2在神经母细胞瘤中表达显著下调，提示其作为肿瘤抑制因子的潜在临床意义。
**建议**：实际文献可通过PubMed、Google Scholar等平台以关键词“DMRTA2 antibody”或“Dmrta2 function”检索，或参考抗体供应商(如Abcam、Sigma-Aldrich)的技术文档。
DMRTA2 (Doublesex and Mab-3 Related Transcription Factor A2) is a member of the DMRT gene family, which encodes zinc finger-like transcription factors involved in developmental processes, particularly sex determination and differentiation. DMRTA2 is evolutionarily conserved and plays critical roles in embryonic development, including neurogenesis and cortical patterning. Studies suggest its involvement in regulating neural progenitor cell proliferation, differentiation, and regional identity in the developing brain. Dysregulation of DMRTA2 has been linked to neurodevelopmental disorders and certain cancers, such as neuroblastoma.
Antibodies targeting DMRTA2 are essential tools for investigating its expression, localization, and function. These antibodies are typically produced using immunogenic peptides or recombinant protein fragments specific to conserved regions of DMRTA2. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect endogenous DMRTA2 protein in tissues or cell lines. Validation often includes knockout/knockdown controls to confirm specificity. Commercially available DMRTA2 antibodies vary in host species (e.g., rabbit, mouse) and clonality (polyclonal/monoclonal), with applications spanning developmental biology, neuroscience, and cancer research. Recent studies have utilized these antibodies to explore DMRTA2's role in brain malformations and tumorigenesis, highlighting its potential as a therapeutic target or biomarker.
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