Rabbit Polyclonal DIP2B Antibody

The DIP2B (Disco-interacting protein 2 homolog B) antibody is a tool used to study the DIP2B protein, which is encoded by the *DIP2B* gene. DIP2B is part of the DIP2 protein family, initially identified for their interaction with Disco proteins in *Drosophila*, and is implicated in neurodevelopment and synaptic function. Structurally, DIP2B contains conserved domains, including a DMAP1-binding domain and a putative acetyltransferase region, suggesting roles in epigenetic regulation or protein acetylation. Research links *DIP2B* mutations to neurodevelopmental disorders, such as autism spectrum disorder (ASD), intellectual disability, and schizophrenia, with animal models showing its involvement in dendritic morphogenesis and neuronal connectivity. The antibody enables detection and localization of DIP2B in tissues or cultured cells, aiding investigations into its expression patterns, molecular interactions, and functional mechanisms. It is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies employing DIP2B antibodies have highlighted its potential as a biomarker or therapeutic target, particularly in disorders involving synaptic dysfunction. Further research is needed to fully elucidate its biological pathways and disease relevance.