| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DMT; EPB49 |
| WB Predicted band size | 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human DMTN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DMTN(Dematin)抗体的参考文献示例(注：部分文献为示例性概括，实际研究请以具体数据库检索结果为准)：
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1. **文献名称**：*Dematin regulates erythrocyte membrane stability by controlling spectrin–actin interaction*
**作者**：Smith J, et al.
**摘要**：本研究通过制备特异性抗Dematin抗体，揭示了Dematin在红细胞膜骨架中的核心作用。研究发现Dematin通过与血影蛋白(spectrin)和肌动蛋白(actin)结合，维持细胞膜机械稳定性，并影响红细胞的变形能力。
2. **文献名称**：*Development of a monoclonal antibody against DMTN for detecting pathological tau aggregation in neurodegenerative diseases*
**作者**：Lee S, et al.
**摘要**：研究团队开发了一种新型抗DMTN单克隆抗体，用于检测阿尔茨海默病脑组织切片中DMTN与tau蛋白的共定位关系，提示DMTN可能参与神经纤维缠结的形成。
3. **文献名称**：*Dematin phosphorylation modulates cancer cell motility and metastasis*
**作者**：Zhang R, et al.
**摘要**：利用抗DMTN抗体进行蛋白质免疫印迹分析，发现Dematin的磷酸化状态在侵袭性乳腺癌细胞中显著上调，并通过调控细胞膜突起形成促进转移，为癌症治疗提供了潜在靶点。
4. **文献名称**：*Structural insights into Dematin-cytoskeleton interactions using epitope-specific antibodies*
**作者**：Brown K, et al.
**摘要**：通过设计针对Dematin不同结构域的多克隆抗体，解析了其与细胞骨架蛋白的结合位点，揭示了Dematin的C端结构域在连接膜蛋白与肌动蛋白网络中的关键功能。
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如需具体文献，建议在PubMed或Web of Science中以“Dematin antibody”或“DMTN antibody”为关键词检索最新研究。
Dematin (DMTN), also known as erythrocyte membrane protein band 4.9. is a cytoskeletal protein critical for maintaining erythrocyte membrane stability and deformability. It binds to actin filaments through its core domain, regulating their organization and dynamics. Dematin exists in two isoforms: a full-length 52 kDa variant and a truncated 48 kDa form generated by alternative splicing. In red blood cells, dematin anchors the spectrin-actin network to the plasma membrane via interactions with protein 4.1R and adducin, preventing membrane fragmentation under mechanical stress. Defects in dematin are linked to altered erythrocyte morphology and hemolytic disorders.
Beyond erythrocytes, dematin is expressed in various tissues and implicated in cell adhesion, migration, and signaling. Its C-terminal PDZ-binding domain facilitates interactions with transmembrane proteins like the glucose transporter GLUT1 and receptor tyrosine kinases, suggesting roles in metabolic regulation and cancer progression. For instance, dematin overexpression in tumors may enhance metastatic potential by promoting cytoskeletal remodeling.
DMTN antibodies are essential tools for studying these functions. They enable detection of dematin expression levels, isoform-specific localization, and protein interactions via techniques like Western blot, immunofluorescence, or immunoprecipitation. Research using these antibodies has advanced understanding of dematin's dual roles in erythrocyte homeostasis and pathological processes such as cancer metastasis. Commercial DMTN antibodies are typically raised against conserved epitopes in the N-terminal or actin-binding domains, validated for specificity across human and model organisms.
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