| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DAP4; DLP4; DAP-4; SAPAP4; SAPAP-4 |
| WB Predicted band size | 108 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human DLGAP4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DLGAP4抗体的3篇参考文献(均为虚构示例，实际文献需通过学术数据库检索)：
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1. **文献名称**: *DLGAP4 Antibody Localization and Function in Synaptic Plasticity*
**作者**: Smith A, et al.
**摘要**: 该研究通过特异性DLGAP4抗体，揭示了其在小鼠海马神经元突触后膜的高表达，并证明DLGAP4与PSD-95的相互作用对突触可塑性和学习记忆功能至关重要。
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2. **文献名称**: *Association of DLGAP4 Autoantibodies with Neuropsychiatric Disorders*
**作者**: Chen L, et al.
**摘要**: 研究利用DLGAP4抗体检测精神分裂症患者血清，发现部分患者存在自身抗体，提示DLGAP4异常免疫反应可能与神经突触功能障碍及疾病病理相关。
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3. **文献名称**: *Developmental Expression Profile of DLGAP4 in the Rodent Brain*
**作者**: Tanaka K, et al.
**摘要**: 通过免疫组化结合DLGAP4特异性抗体，分析了该蛋白在大鼠大脑发育过程中的时空表达模式，发现其在皮层和纹状体早期突触形成阶段显著上调。
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**注**：实际文献需通过PubMed、Google Scholar等平台以关键词“DLGAP4 antibody”或“DLGAP4 + 研究领域”检索，并关注抗体应用(如WB/IHC)或疾病关联研究。
The DLGAP4 antibody targets Discs Large Homolog-Associated Protein 4 (DLGAP4), a member of the SAPAP family of synaptic scaffolding proteins. DLGAP4. also known as SAPAP4. is predominantly expressed in the brain, particularly within the postsynaptic density (PSD) of neurons. It interacts with other PSD proteins, such as PSD-95. to organize synaptic signaling complexes and maintain synaptic structure and function. DLGAP4 contains conserved domains, including PDZ-binding motifs, enabling its role in anchoring receptors, ion channels, and signaling molecules at synapses.
DLGAP4 antibodies are widely used in neuroscience research to study synaptic protein networks, neuronal development, and plasticity. Altered DLGAP4 expression has been linked to neuropsychiatric disorders, including autism spectrum disorders and schizophrenia, highlighting its potential role in synaptic dysfunction. Recent studies also implicate DLGAP4 in cancer, where its dysregulation may influence cell adhesion and signaling pathways, such as MAPK/ERK, in tumors like prostate cancer.
As a research tool, DLGAP4 antibodies enable detection via techniques like Western blot, immunohistochemistry, and immunofluorescence, aiding investigations into protein localization, expression levels, and interactions. However, antibody specificity remains a critical consideration, requiring validation through knockout controls. Ongoing research continues to explore DLGAP4's dual roles in neuronal health and disease, as well as its emerging connections to oncogenic processes.
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