Rabbit Polyclonal DND1 Antibody

The DND1 (Dead-End Protein 1) antibody is a tool used to study the DND1 protein, a critical RNA-binding factor involved in germ cell development and maintenance. DND1 plays a key role in post-transcriptional gene regulation by stabilizing target mRNAs and counteracting microRNA-mediated repression, ensuring proper germline stem cell survival and differentiation. It is particularly vital during embryonic development, as DND1-deficient mice exhibit sterility and germ cell depletion. In humans, DND1 mutations are linked to susceptibility to testicular germ cell tumors. The antibody is widely employed in research to detect DND1 expression in tissues (e.g., testes, ovaries) or cell lines via techniques like Western blot, immunohistochemistry, and immunofluorescence. Studies using DND1 antibodies have clarified its interaction with RNA machinery (e.g., binding to the 3' untranslated regions of mRNAs like NANOG) and its role in primordial germ cell migration. Its dysregulation is also implicated in fertility disorders and oncogenesis, making the antibody valuable for reproductive biology and cancer research. Commercial DND1 antibodies are typically developed in rabbits or mice, targeting specific epitopes of human or mouse DND1. with validation in knockout models to ensure specificity.